6EL9
Glucocorticoid Receptor in complex with AZD9567
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Glucocorticoid receptor | polymer | 280 | 32030.0 | 1 | UniProt (P04150) Pfam (PF00104) In PDB | Homo sapiens (Human) | GR,Nuclear receptor subfamily 3 group C member 1 |
| 2 | B | Nuclear receptor coactivator 2 | polymer | 14 | 1708.9 | 1 | UniProt (Q15596) In PDB | Homo sapiens | NCoA-2,Class E basic helix-loop-helix protein 75,bHLHe75,Transcriptional intermediary factor 2,hTIF2 |
| 3 | A | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 4 | A | 2,2-bis(fluoranyl)-~{N}-[(1~{R},2~{S})-3-methyl-1-[1-(1-methyl-6-oxidanylidene-pyridin-3-yl)indazol-5-yl]oxy-1-phenyl-butan-2-yl]propanamide | non-polymer | 494.5 | 1 | Chemie (B9W) | |||
| 5 | water | water | 18.0 | 63 | Chemie (HOH) |
Sequence modifications
A: 500 - 777 (UniProt: P04150)
| PDB | External Database | Details |
|---|---|---|
| Gly 498 | - | expression tag |
| Ser 499 | - | expression tag |
| Asp 517 | Asn 517 | engineered mutation |
| Met 571 | Val 571 | engineered mutation |
| Ser 602 | Phe 602 | engineered mutation |
| Asp 638 | Cys 638 | engineered mutation |
| Ala 684 | Glu 684 | engineered mutation |
| Ser 712 | Trp 712 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 33738.9 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 556.6 | |
| All* | Total formula weight | 34295.5 |
