6EJ1
Crystal structure of KDM5B in complex with KDOPZ48a.
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Lysine-specific demethylase 5B,Lysine-specific demethylase 5B | polymer | 459 | 52911.7 | 1 | UniProt (Q9UGL1) Pfam (PF02375) Pfam (PF02373) Pfam (PF21323) Pfam (PF02928) In PDB | Homo sapiens (Human) | Cancer/testis antigen 31,CT31,Histone demethylase JARID1B,Jumonji/ARID domain-containing protein 1B,PLU-1,Retinoblastoma-binding protein 2 homolog 1,RBP2-H1,Cancer/testis antigen 31,CT31,Histone demethylase JARID1B,Jumonji/ARID domain-containing protein 1B,PLU-1,Retinoblastoma-binding protein 2 homolog 1,RBP2-H1 |
2 | A | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
3 | A | MANGANESE (II) ION | non-polymer | 54.9 | 2 | Chemie (MN) | |||
4 | A | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 3 | Chemie (DMS) | |||
5 | A | 5-[1-[1-(2-chloranylethanoyl)piperidin-4-yl]pyrazol-4-yl]-7-oxidanylidene-6-propan-2-yl-4~{H}-pyrazolo[1,5-a]pyrimidine-3-carbonitrile | non-polymer | 427.9 | 1 | Chemie (B7Q) | |||
6 | A | 1,2-ETHANEDIOL | non-polymer | 62.1 | 2 | Chemie (EDO) | |||
7 | water | water | 18.0 | 244 | Chemie (HOH) |
Sequence modifications
A: 26 - 98 (UniProt: Q9UGL1)
A: 375 - 754 (UniProt: Q9UGL1)
PDB | External Database | Details |
---|---|---|
Met 25 | - | initiating methionine |
PDB | External Database | Details |
---|---|---|
Gly 370 | - | linker |
Gly 371 | - | linker |
Gly 372 | - | linker |
Gly 373 | - | linker |
Gly 374 | - | linker |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 52911.7 | |
Non-Polymers* | Number of molecules | 9 |
Total formula weight | 961.7 | |
All* | Total formula weight | 53873.4 |