6EIU
Crystal structure of KDM5B in complex with KDOPZ29a
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Lysine-specific demethylase 5B,Lysine-specific demethylase 5B | polymer | 462 | 53267.2 | 1 | UniProt (Q9UGL1) Pfam (PF02375) Pfam (PF02373) Pfam (PF21323) Pfam (PF02928) | Homo sapiens (Human) | Cancer/testis antigen 31,CT31,Histone demethylase JARID1B,Jumonji/ARID domain-containing protein 1B,PLU-1,Retinoblastoma-binding protein 2 homolog 1,RBP2-H1,Cancer/testis antigen 31,CT31,Histone demethylase JARID1B,Jumonji/ARID domain-containing protein 1B,PLU-1,Retinoblastoma-binding protein 2 homolog 1,RBP2-H1 |
| 2 | B, R (A) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 3 | C, D (A) | MANGANESE (II) ION | non-polymer | 54.9 | 2 | Chemie (MN) | |||
| 4 | E (A) | 8-oxidanyl-6-phenyl-7-propan-2-yl-imidazo[1,2-b]pyridazine-3-carbonitrile | non-polymer | 278.3 | 1 | Chemie (B6T) | |||
| 5 | F, G, H, I, J... (A) | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 7 | Chemie (DMS) | |||
| 6 | M, N, O, P, Q (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 5 | Chemie (EDO) | |||
| 7 | S (A) | water | water | 18.0 | 280 | Chemie (HOH) |
Sequence modifications
A: 26 - 100 (UniProt: Q9UGL1)
A: 374 - 754 (UniProt: Q9UGL1)
| PDB | External Database | Details |
|---|---|---|
| Met 25 | - | initiating methionine |
| PDB | External Database | Details |
|---|---|---|
| Leu 369 | - | linker |
| Gly 370 | - | linker |
| Gly 371 | - | linker |
| Gly 372 | - | linker |
| Gly 373 | - | linker |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 53267.2 | |
| Non-Polymers* | Number of molecules | 17 |
| Total formula weight | 1376.3 | |
| All* | Total formula weight | 54643.4 |
