6EIU

Crystal structure of KDM5B in complex with KDOPZ29a

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN A 801

Chain	Residue
A	CYS692
A	CYS695
A	CYS715
A	HIS718

---

site_id	AC2
Number of Residues	5
Details	binding site for residue MN A 802

Chain	Residue
A	LEU90
A	ASN91
A	LEU413
A	GLU419
A	HOH903

---

site_id	AC3
Number of Residues	6
Details	binding site for residue MN A 803

Chain	Residue
A	HIS499
A	GLU501
A	HIS587
A	B6T804
A	HOH934
A	HOH1044

---

site_id	AC4
Number of Residues	16
Details	binding site for residue B6T A 804

Chain	Residue
A	ARG98
A	TYR425
A	ALA427
A	TYR488
A	PHE496
A	HIS499
A	ASN509
A	LYS517
A	HIS587
A	ASN591
A	MN803
A	DMS805
A	HOH902
A	HOH934
A	HOH1044
A	HOH1106

---

site_id	AC5
Number of Residues	9
Details	binding site for residue DMS A 805

Chain	Residue
A	GLN88
A	GLN96
A	THR97
A	TYR425
A	SER495
A	PHE496
A	CYS497
A	B6T804
A	HOH988

---

site_id	AC6
Number of Residues	5
Details	binding site for residue DMS A 806

Chain	Residue
A	ARG98
A	VAL99
A	TRP486
A	TYR488
A	DMS807

---

site_id	AC7
Number of Residues	8
Details	binding site for residue DMS A 807

Chain	Residue
A	TRP486
A	TYR488
A	SER507
A	ALA599
A	VAL600
A	ASN601
A	DMS806
A	HOH1044

---

site_id	AC8
Number of Residues	6
Details	binding site for residue DMS A 808

Chain	Residue
A	TRP504
A	ARG584
A	HIS617
A	TYR618
A	LEU621
A	ARG623

---

site_id	AC9
Number of Residues	3
Details	binding site for residue DMS A 809

Chain	Residue
A	HIS622
A	HIS718
A	HOH1041

---

site_id	AD1
Number of Residues	4
Details	binding site for residue DMS A 810

Chain	Residue
A	GLU631
A	LYS635
A	GLU683
A	TYR736

---

site_id	AD2
Number of Residues	5
Details	binding site for residue DMS A 811

Chain	Residue
A	ARG666
A	SER677
A	LEU732
A	THR737
A	HOH1029

---

site_id	AD3
Number of Residues	6
Details	binding site for residue EDO A 812

Chain	Residue
A	PHE83
A	GLY426
A	ALA427
A	ASP428
A	LEU487
A	VAL489

---

site_id	AD4
Number of Residues	8
Details	binding site for residue EDO A 813

Chain	Residue
A	VAL615
A	TYR618
A	ARG619
A	ARG623
A	CYS625
A	CYS695
A	LYS696
A	THR697

---

site_id	AD5
Number of Residues	5
Details	binding site for residue EDO A 814

Chain	Residue
A	ARG670
A	VAL674
A	ILE675
A	HOH910
A	HOH957

---

site_id	AD6
Number of Residues	4
Details	binding site for residue EDO A 815

Chain	Residue
A	ARG612
A	ASP630
A	MET658
A	GLU662

---

site_id	AD7
Number of Residues	7
Details	binding site for residue EDO A 816

Chain	Residue
A	GLY711
A	LEU713
A	ASP688
A	GLU689
A	ARG690
A	GLN691
A	VAL693

---

site_id	AD8
Number of Residues	4
Details	binding site for residue ZN A 817

Chain	Residue
A	CYS706
A	CYS708
A	CYS723
A	CYS725

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	41
Details	Domain: {"description":"JmjN","evidences":[{"source":"PROSITE-ProRule","id":"PRU00537","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	166
Details	Domain: {"description":"JmjC","evidences":[{"source":"PROSITE-ProRule","id":"PRU00538","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	52
Details	Zinc finger: {"description":"C5HC2","evidences":[{"source":"PubMed","id":"26741168","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27214403","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28262558","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P29375","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"26741168","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"27214403","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"28262558","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---