6EIN
Crystal structure of KDM5B in complex with S49365a.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Lysine-specific demethylase 5B,Lysine-specific demethylase 5B | polymer | 481 | 55457.6 | 1 | UniProt (Q9UGL1) Pfam (PF02375) Pfam (PF02373) Pfam (PF21323) Pfam (PF02928) | Homo sapiens (Human) | Cancer/testis antigen 31,CT31,Histone demethylase JARID1B,Jumonji/ARID domain-containing protein 1B,PLU-1,Retinoblastoma-binding protein 2 homolog 1,RBP2-H1,Cancer/testis antigen 31,CT31,Histone demethylase JARID1B,Jumonji/ARID domain-containing protein 1B,PLU-1,Retinoblastoma-binding protein 2 homolog 1,RBP2-H1 |
| 2 | B (A) | 8-[4-[2-(4-propanoylpiperazin-1-yl)ethyl]pyrazol-1-yl]-3~{H}-pyrido[3,4-d]pyrimidin-4-one | non-polymer | 381.4 | 1 | Chemie (B7Z) | |||
| 3 | C (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 4 | D, E (A) | MANGANESE (II) ION | non-polymer | 54.9 | 2 | Chemie (MN) | |||
| 5 | F, G, H, I (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 4 | Chemie (EDO) | |||
| 6 | J (A) | water | water | 18.0 | 213 | Chemie (HOH) |
Sequence modifications
A: 26 - 369 (UniProt: Q9UGL1)
A: 374 - 772 (UniProt: Q9UGL1)
| PDB | External Database | Details |
|---|---|---|
| Ser 24 | - | expression tag |
| Met 25 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 370 | - | linker |
| Gly 371 | - | linker |
| Gly 372 | - | linker |
| Gly 373 | - | linker |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 55457.6 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 805.0 | |
| All* | Total formula weight | 56262.6 |
