6EH3
Crystal Structure of the Protein-Kinase A catalytic subunit from Criteculus Griseus in complex with compounds RKp120 and RKp190
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | cAMP-dependent protein kinase catalytic subunit alpha | polymer | 353 | 41193.7 | 1 | UniProt (P25321) Pfam (PF00069) | Cricetulus griseus (Chinese hamster) | PKA C-alpha |
| 2 | B (C) | cAMP-dependent protein kinase inhibitor | polymer | 18 | 1946.2 | 1 | UniProt (by SIFTS) (G3HK48) | Cricetulus griseus | |
| 3 | C (A) | ~{N}-[2-[(phenylmethyl)amino]ethyl]isoquinoline-5-sulfonamide | non-polymer | 341.4 | 1 | Chemie (B4Z) | |||
| 4 | D, E (A, C) | water | water | 18.0 | 151 | Chemie (HOH) |
Sequence modifications
A: 0 - 350 (UniProt: P25321)
| PDB | External Database | Details |
|---|---|---|
| Gly -2 | - | expression tag |
| His -1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 43139.9 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 341.4 | |
| All* | Total formula weight | 43481.3 |
