6EGF
Crystal structure of the inactive unphosphorylated IRAK4 kinase domain bound to AMP-PNP
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (B) | Interleukin-1 receptor-associated kinase 4 | polymer | 302 | 33716.3 | 1 | UniProt (Q9NWZ3) Pfam (PF07714) | Homo sapiens (Human) | IRAK-4,Renal carcinoma antigen NY-REN-64 |
| 2 | B (B) | PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | non-polymer | 506.2 | 1 | Chemie (ANP) | |||
| 3 | C, D (B) | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
| 4 | E (B) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 5 | F (B) | water | water | 18.0 | 40 | Chemie (HOH) |
Sequence modifications
B: 164 - 460 (UniProt: Q9NWZ3)
| PDB | External Database | Details |
|---|---|---|
| Gly 159 | - | expression tag |
| Ala 160 | - | expression tag |
| Met 161 | - | expression tag |
| Gly 162 | - | expression tag |
| Ser 163 | - | expression tag |
| Asn 311 | Asp 311 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 33716.3 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 722.6 | |
| All* | Total formula weight | 34439.0 |
