6EGF
Crystal structure of the inactive unphosphorylated IRAK4 kinase domain bound to AMP-PNP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| B | 0000287 | molecular_function | magnesium ion binding |
| B | 0004672 | molecular_function | protein kinase activity |
| B | 0004674 | molecular_function | protein serine/threonine kinase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0006468 | biological_process | protein phosphorylation |
| B | 0007165 | biological_process | signal transduction |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 18 |
| Details | binding site for residue ANP B 501 |
| Chain | Residue |
| B | MET192 |
| B | SER269 |
| B | ASN311 |
| B | LYS313 |
| B | ALA315 |
| B | ASN316 |
| B | LEU318 |
| B | ASP329 |
| B | MG504 |
| B | HOH631 |
| B | GLU194 |
| B | GLY195 |
| B | GLY196 |
| B | VAL200 |
| B | ALA211 |
| B | LYS213 |
| B | VAL263 |
| B | MET265 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 B 502 |
| Chain | Residue |
| B | HIS438 |
| B | GLU439 |
| B | LYS440 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 B 503 |
| Chain | Residue |
| B | HIS307 |
| B | ILE308 |
| B | ARG334 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | binding site for residue MG B 504 |
| Chain | Residue |
| B | ASN316 |
| B | ASP329 |
| B | ANP501 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159 |
| Chain | Residue | Details |
| B | ASN311 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 |
| Chain | Residue | Details |
| B | MET192 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | BINDING: |
| Chain | Residue | Details |
| B | LYS213 | |
| B | LYS313 | |
| B | ASP329 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine => ECO:0000269|PubMed:17312103, ECO:0000269|Ref.32 |
| Chain | Residue | Details |
| B | THR342 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine => ECO:0000269|PubMed:17161373, ECO:0000269|PubMed:17312103, ECO:0000269|Ref.32 |
| Chain | Residue | Details |
| B | THR345 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0000269|PubMed:17161373, ECO:0000269|PubMed:17312103 |
| Chain | Residue | Details |
| B | SER346 |
