6ECP
The human methylenetetrahydrofolate dehydrogenase/cyclohydrolase (FolD) complexed with NADP and inhibitor LY249543
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Methylenetetrahydrofolate dehydrogenase cyclohydrolase | polymer | 306 | 33338.4 | 2 | UniProt (P11586) Pfam (PF00763) Pfam (PF02882) In PDB | Homo sapiens (Human) | C1-THF synthase |
2 | A, B | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 743.4 | 2 | Chemie (NAP) | |||
3 | A | N-(4-{2-[(6S)-2-amino-4-oxo-1,4,5,6,7,8-hexahydropyrido[2,3-d]pyrimidin-6-yl]ethyl}benzoyl)-L-glutamic acid | non-polymer | 443.5 | 2 | Chemie (21V) | |||
4 | water | water | 18.0 | 195 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 66676.8 | |
Non-Polymers* | Number of molecules | 4 |
Total formula weight | 2373.7 | |
All* | Total formula weight | 69050.6 |