6ECP

The human methylenetetrahydrofolate dehydrogenase/cyclohydrolase (FolD) complexed with NADP and inhibitor LY249543

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Methylenetetrahydrofolate dehydrogenase cyclohydrolase	polymer	306	33338.4	2	UniProt (P11586) Pfam (PF00763) Pfam (PF02882)	Homo sapiens (Human)	C1-THF synthase
2	C, F (A, B)	NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE	non-polymer		743.4	2	Chemie (NAP)
3	D, E (A)	N-(4-{2-[(6S)-2-amino-4-oxo-1,4,5,6,7,8-hexahydropyrido[2,3-d]pyrimidin-6-yl]ethyl}benzoyl)-L-glutamic acid	non-polymer		443.5	2	Chemie (21V)
4	G, H (A, B)	water	water		18.0	195	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	66676.8
Non-Polymers*	Number of molecules	4
	Total formula weight	2373.7
All*	Total formula weight	69050.6

*Water molecules are not included.