Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004488 | molecular_function | methylenetetrahydrofolate dehydrogenase (NADP+) activity |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004488 | molecular_function | methylenetetrahydrofolate dehydrogenase (NADP+) activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 20 |
| Details | binding site for residue NAP A 403 |
| Chain | Residue |
| A | THR148 |
| A | THR216 |
| A | GLY217 |
| A | GLN218 |
| A | CYS236 |
| A | GLY237 |
| A | ILE238 |
| A | GLY276 |
| A | THR279 |
| A | 21V401 |
| A | 21V402 |
| A | GLY172 |
| A | HOH517 |
| A | ARG173 |
| A | SER174 |
| A | VAL177 |
| A | HIS196 |
| A | SER197 |
| A | LEU202 |
| A | ALA215 |
| site_id | AC2 |
| Number of Residues | 22 |
| Details | binding site for residue NAP B 401 |
| Chain | Residue |
| B | THR148 |
| B | GLY172 |
| B | ARG173 |
| B | SER174 |
| B | VAL177 |
| B | HIS196 |
| B | SER197 |
| B | LEU202 |
| B | ALA215 |
| B | THR216 |
| B | GLY217 |
| B | GLN218 |
| B | MET221 |
| B | CYS236 |
| B | GLY237 |
| B | ILE238 |
| B | THR279 |
| B | HOH513 |
| B | HOH518 |
| B | HOH522 |
| B | HOH524 |
| B | HOH556 |
| site_id | AC3 |
| Number of Residues | 14 |
| Details | binding site for residues 21V A 402 and 21V A 403 |
| Chain | Residue |
| A | TYR52 |
| A | VAL55 |
| A | LYS56 |
| A | GLN100 |
| A | LEU101 |
| A | ILE238 |
| A | PRO272 |
| A | GLY273 |
| A | GLY276 |
| A | VAL280 |
| A | NAP403 |
| A | HOH512 |
| A | HOH518 |
| A | HOH560 |
| site_id | AC4 |
| Number of Residues | 14 |
| Details | binding site for residues 21V A 402 and 21V A 403 |
| Chain | Residue |
| A | TYR52 |
| A | VAL55 |
| A | LYS56 |
| A | GLN100 |
| A | LEU101 |
| A | ILE238 |
| A | PRO272 |
| A | GLY273 |
| A | GLY276 |
| A | VAL280 |
| A | NAP403 |
| A | HOH512 |
| A | HOH518 |
| A | HOH560 |
| site_id | AC5 |
| Number of Residues | 14 |
| Details | binding site for residues 21V A 402 and 21V A 403 |
| Chain | Residue |
| A | TYR52 |
| A | VAL55 |
| A | LYS56 |
| A | GLN100 |
| A | LEU101 |
| A | ILE238 |
| A | PRO272 |
| A | GLY273 |
| A | GLY276 |
| A | VAL280 |
| A | NAP403 |
| A | HOH512 |
| A | HOH518 |
| A | HOH560 |
| site_id | AC6 |
| Number of Residues | 14 |
| Details | binding site for residues 21V A 402 and 21V A 403 |
| Chain | Residue |
| A | TYR52 |
| A | VAL55 |
| A | LYS56 |
| A | GLN100 |
| A | LEU101 |
| A | ILE238 |
| A | PRO272 |
| A | GLY273 |
| A | GLY276 |
| A | VAL280 |
| A | NAP403 |
| A | HOH512 |
| A | HOH518 |
| A | HOH560 |
| site_id | AC7 |
| Number of Residues | 14 |
| Details | binding site for residues 21V A 402 and 21V A 403 |
| Chain | Residue |
| A | VAL55 |
| A | LYS56 |
| A | GLN100 |
| A | LEU101 |
| A | ILE238 |
| A | PRO272 |
| A | GLY273 |
| A | GLY276 |
| A | VAL280 |
| A | NAP403 |
| A | HOH512 |
| A | HOH518 |
| A | HOH560 |
| A | TYR52 |
| site_id | AC8 |
| Number of Residues | 14 |
| Details | binding site for residues 21V A 402 and 21V A 403 |
| Chain | Residue |
| A | TYR52 |
| A | VAL55 |
| A | LYS56 |
| A | GLN100 |
| A | LEU101 |
| A | ILE238 |
| A | PRO272 |
| A | GLY273 |
| A | GLY276 |
| A | VAL280 |
| A | NAP403 |
| A | HOH512 |
| A | HOH518 |
| A | HOH560 |
| site_id | AC9 |
| Number of Residues | 14 |
| Details | binding site for residues 21V A 402 and 21V A 403 |
| Chain | Residue |
| A | TYR52 |
| A | VAL55 |
| A | LYS56 |
| A | GLN100 |
| A | LEU101 |
| A | ILE238 |
| A | PRO272 |
| A | GLY273 |
| A | GLY276 |
| A | VAL280 |
| A | NAP403 |
| A | HOH512 |
| A | HOH518 |
| A | HOH560 |
| site_id | AD1 |
| Number of Residues | 14 |
| Details | binding site for residues 21V A 402 and 21V A 403 |
| Chain | Residue |
| A | TYR52 |
| A | VAL55 |
| A | LYS56 |
| A | GLN100 |
| A | LEU101 |
| A | ILE238 |
| A | PRO272 |
| A | GLY273 |
| A | GLY276 |
| A | VAL280 |
| A | NAP403 |
| A | HOH512 |
| A | HOH518 |
| A | HOH560 |
| site_id | AD2 |
| Number of Residues | 14 |
| Details | binding site for residues 21V A 402 and 21V A 403 |
| Chain | Residue |
| A | TYR52 |
| A | VAL55 |
| A | LYS56 |
| A | GLN100 |
| A | LEU101 |
| A | ILE238 |
| A | PRO272 |
| A | GLY273 |
| A | GLY276 |
| A | VAL280 |
| A | NAP403 |
| A | HOH512 |
| A | HOH518 |
| A | HOH560 |
| site_id | AD3 |
| Number of Residues | 14 |
| Details | binding site for residues 21V A 402 and 21V A 403 |
| Chain | Residue |
| A | TYR52 |
| A | VAL55 |
| A | LYS56 |
| A | GLN100 |
| A | LEU101 |
| A | ILE238 |
| A | PRO272 |
| A | GLY273 |
| A | GLY276 |
| A | VAL280 |
| A | NAP403 |
| A | HOH512 |
| A | HOH518 |
| A | HOH560 |
| site_id | AD4 |
| Number of Residues | 14 |
| Details | binding site for residues 21V A 402 and 21V A 403 |
| Chain | Residue |
| A | TYR52 |
| A | VAL55 |
| A | LYS56 |
| A | GLN100 |
| A | LEU101 |
| A | ILE238 |
| A | PRO272 |
| A | GLY273 |
| A | GLY276 |
| A | VAL280 |
| A | NAP403 |
| A | HOH512 |
| A | HOH518 |
| A | HOH560 |
| site_id | AD5 |
| Number of Residues | 14 |
| Details | binding site for residues 21V A 402 and 21V A 403 |
| Chain | Residue |
| A | TYR52 |
| A | VAL55 |
| A | LYS56 |
| A | GLN100 |
| A | LEU101 |
| A | ILE238 |
| A | PRO272 |
| A | GLY273 |
| A | GLY276 |
| A | VAL280 |
| A | NAP403 |
| A | HOH512 |
| A | HOH518 |
| A | HOH560 |
| site_id | AD6 |
| Number of Residues | 14 |
| Details | binding site for residues 21V A 402 and 21V A 403 |
| Chain | Residue |
| A | TYR52 |
| A | VAL55 |
| A | LYS56 |
| A | GLN100 |
| A | LEU101 |
| A | ILE238 |
| A | PRO272 |
| A | GLY273 |
| A | GLY276 |
| A | VAL280 |
| A | NAP403 |
| A | HOH512 |
| A | HOH518 |
| A | HOH560 |
| site_id | AD7 |
| Number of Residues | 14 |
| Details | binding site for residues 21V A 402 and 21V A 403 |
| Chain | Residue |
| A | TYR52 |
| A | VAL55 |
| A | LYS56 |
| A | GLN100 |
| A | LEU101 |
| A | ILE238 |
| A | PRO272 |
| A | GLY273 |
| A | GLY276 |
| A | VAL280 |
| A | NAP403 |
| A | HOH512 |
| A | HOH518 |
| A | HOH560 |
| site_id | AD8 |
| Number of Residues | 14 |
| Details | binding site for residues 21V A 402 and 21V A 403 |
| Chain | Residue |
| A | TYR52 |
| A | VAL55 |
| A | LYS56 |
| A | GLN100 |
| A | LEU101 |
| A | ILE238 |
| A | PRO272 |
| A | GLY273 |
| A | GLY276 |
| A | VAL280 |
| A | NAP403 |
| A | HOH512 |
| A | HOH518 |
| A | HOH560 |
| site_id | AD9 |
| Number of Residues | 14 |
| Details | binding site for residues 21V A 402 and 21V A 403 |
| Chain | Residue |
| A | TYR52 |
| A | VAL55 |
| A | LYS56 |
| A | GLN100 |
| A | LEU101 |
| A | ILE238 |
| A | PRO272 |
| A | GLY273 |
| A | GLY276 |
| A | VAL280 |
| A | NAP403 |
| A | HOH512 |
| A | HOH518 |
| A | HOH560 |
| site_id | AE1 |
| Number of Residues | 14 |
| Details | binding site for residues 21V A 402 and 21V A 403 |
| Chain | Residue |
| A | TYR52 |
| A | VAL55 |
| A | LYS56 |
| A | GLN100 |
| A | LEU101 |
| A | ILE238 |
| A | PRO272 |
| A | GLY273 |
| A | GLY276 |
| A | VAL280 |
| A | NAP403 |
| A | HOH512 |
| A | HOH518 |
| A | HOH560 |
| site_id | AE2 |
| Number of Residues | 14 |
| Details | binding site for residues 21V A 402 and 21V A 403 |
| Chain | Residue |
| A | TYR52 |
| A | VAL55 |
| A | LYS56 |
| A | GLN100 |
| A | LEU101 |
| A | ILE238 |
| A | PRO272 |
| A | GLY273 |
| A | GLY276 |
| A | VAL280 |
| A | NAP403 |
| A | HOH512 |
| A | HOH518 |
| A | HOH560 |
| site_id | AE3 |
| Number of Residues | 14 |
| Details | binding site for residues 21V A 402 and 21V A 403 |
| Chain | Residue |
| A | TYR52 |
| A | VAL55 |
| A | LYS56 |
| A | GLN100 |
| A | LEU101 |
| A | ILE238 |
| A | PRO272 |
| A | GLY273 |
| A | GLY276 |
| A | VAL280 |
| A | NAP403 |
| A | HOH512 |
| A | HOH518 |
| A | HOH560 |
| site_id | AE4 |
| Number of Residues | 14 |
| Details | binding site for residues 21V A 402 and 21V A 403 |
| Chain | Residue |
| A | TYR52 |
| A | VAL55 |
| A | LYS56 |
| A | GLN100 |
| A | LEU101 |
| A | ILE238 |
| A | PRO272 |
| A | GLY273 |
| A | GLY276 |
| A | VAL280 |
| A | NAP403 |
| A | HOH512 |
| A | HOH518 |
| A | HOH560 |
| site_id | AE5 |
| Number of Residues | 14 |
| Details | binding site for residues 21V A 402 and 21V A 403 |
| Chain | Residue |
| A | TYR52 |
| A | VAL55 |
| A | LYS56 |
| A | GLN100 |
| A | LEU101 |
| A | ILE238 |
| A | PRO272 |
| A | GLY273 |
| A | GLY276 |
| A | VAL280 |
| A | NAP403 |
| A | HOH512 |
| A | HOH518 |
| A | HOH560 |
| site_id | AE6 |
| Number of Residues | 14 |
| Details | binding site for residues 21V A 402 and 21V A 403 |
| Chain | Residue |
| A | TYR52 |
| A | VAL55 |
| A | LYS56 |
| A | GLN100 |
| A | LEU101 |
| A | ILE238 |
| A | PRO272 |
| A | GLY273 |
| A | GLY276 |
| A | VAL280 |
| A | NAP403 |
| A | HOH512 |
| A | HOH518 |
| A | HOH560 |
| site_id | AE7 |
| Number of Residues | 14 |
| Details | binding site for residues 21V A 402 and 21V A 403 |
| Chain | Residue |
| A | TYR52 |
| A | VAL55 |
| A | LYS56 |
| A | GLN100 |
| A | LEU101 |
| A | ILE238 |
| A | PRO272 |
| A | GLY273 |
| A | GLY276 |
| A | VAL280 |
| A | NAP403 |
| A | HOH512 |
| A | HOH518 |
| A | HOH560 |
| site_id | AE8 |
| Number of Residues | 14 |
| Details | binding site for residues 21V A 402 and 21V A 403 |
| Chain | Residue |
| A | TYR52 |
| A | VAL55 |
| A | LYS56 |
| A | GLN100 |
| A | LEU101 |
| A | ILE238 |
| A | PRO272 |
| A | GLY273 |
| A | GLY276 |
| A | VAL280 |
| A | NAP403 |
| A | HOH512 |
| A | HOH518 |
| A | HOH560 |
| site_id | AE9 |
| Number of Residues | 14 |
| Details | binding site for residues 21V A 402 and 21V A 403 |
| Chain | Residue |
| A | TYR52 |
| A | VAL55 |
| A | LYS56 |
| A | GLN100 |
| A | LEU101 |
| A | ILE238 |
| A | PRO272 |
| A | GLY273 |
| A | GLY276 |
| A | VAL280 |
| A | NAP403 |
| A | HOH512 |
| A | HOH518 |
| A | HOH560 |
| site_id | AF1 |
| Number of Residues | 14 |
| Details | binding site for residues 21V A 402 and 21V A 403 |
| Chain | Residue |
| A | TYR52 |
| A | VAL55 |
| A | LYS56 |
| A | GLN100 |
| A | LEU101 |
| A | ILE238 |
| A | PRO272 |
| A | GLY273 |
| A | GLY276 |
| A | VAL280 |
| A | NAP403 |
| A | HOH512 |
| A | HOH518 |
| A | HOH560 |
| site_id | AF2 |
| Number of Residues | 14 |
| Details | binding site for residues 21V A 402 and 21V A 403 |
| Chain | Residue |
| A | TYR52 |
| A | VAL55 |
| A | LYS56 |
| A | GLN100 |
| A | LEU101 |
| A | ILE238 |
| A | PRO272 |
| A | GLY273 |
| A | GLY276 |
| A | VAL280 |
| A | NAP403 |
| A | HOH512 |
| A | HOH518 |
| A | HOH560 |
| site_id | AF3 |
| Number of Residues | 14 |
| Details | binding site for residues 21V A 402 and 21V A 403 |
| Chain | Residue |
| A | TYR52 |
| A | VAL55 |
| A | LYS56 |
| A | GLN100 |
| A | LEU101 |
| A | ILE238 |
| A | PRO272 |
| A | GLY273 |
| A | GLY276 |
| A | VAL280 |
| A | NAP403 |
| A | HOH512 |
| A | HOH518 |
| A | HOH560 |
| site_id | AF4 |
| Number of Residues | 14 |
| Details | binding site for residues 21V A 402 and 21V A 403 |
| Chain | Residue |
| A | TYR52 |
| A | VAL55 |
| A | LYS56 |
| A | GLN100 |
| A | LEU101 |
| A | ILE238 |
| A | PRO272 |
| A | GLY273 |
| A | GLY276 |
| A | VAL280 |
| A | NAP403 |
| A | HOH512 |
| A | HOH518 |
| A | HOH560 |
| site_id | AF5 |
| Number of Residues | 14 |
| Details | binding site for residues 21V A 402 and 21V A 403 |
| Chain | Residue |
| A | TYR52 |
| A | VAL55 |
| A | LYS56 |
| A | GLN100 |
| A | LEU101 |
| A | ILE238 |
| A | PRO272 |
| A | GLY273 |
| A | GLY276 |
| A | VAL280 |
| A | NAP403 |
| A | HOH512 |
| A | HOH518 |
| A | HOH560 |
| site_id | AF6 |
| Number of Residues | 14 |
| Details | binding site for residues 21V A 402 and 21V A 403 |
| Chain | Residue |
| A | TYR52 |
| A | VAL55 |
| A | LYS56 |
| A | GLN100 |
| A | LEU101 |
| A | ILE238 |
| A | PRO272 |
| A | GLY273 |
| A | GLY276 |
| A | VAL280 |
| A | NAP403 |
| A | HOH512 |
| A | HOH518 |
| A | HOH560 |
| site_id | AF7 |
| Number of Residues | 14 |
| Details | binding site for residues 21V A 402 and 21V A 403 |
| Chain | Residue |
| A | TYR52 |
| A | VAL55 |
| A | LYS56 |
| A | GLN100 |
| A | LEU101 |
| A | ILE238 |
| A | PRO272 |
| A | GLY273 |
| A | GLY276 |
| A | VAL280 |
| A | NAP403 |
| A | HOH512 |
| A | HOH518 |
| A | HOH560 |
| site_id | AF8 |
| Number of Residues | 14 |
| Details | binding site for residues 21V A 402 and 21V A 403 |
| Chain | Residue |
| A | TYR52 |
| A | VAL55 |
| A | LYS56 |
| A | GLN100 |
| A | LEU101 |
| A | ILE238 |
| A | PRO272 |
| A | GLY273 |
| A | GLY276 |
| A | VAL280 |
| A | NAP403 |
| A | HOH512 |
| A | HOH518 |
| A | HOH560 |
| site_id | AF9 |
| Number of Residues | 14 |
| Details | binding site for residues 21V A 402 and 21V A 403 |
| Chain | Residue |
| A | TYR52 |
| A | VAL55 |
| A | LYS56 |
| A | GLN100 |
| A | LEU101 |
| A | ILE238 |
| A | PRO272 |
| A | GLY273 |
| A | GLY276 |
| A | VAL280 |
| A | NAP403 |
| A | HOH512 |
| A | HOH518 |
| A | HOH560 |
| site_id | AG1 |
| Number of Residues | 14 |
| Details | binding site for residues 21V A 402 and 21V A 403 |
| Chain | Residue |
| A | TYR52 |
| A | VAL55 |
| A | LYS56 |
| A | GLN100 |
| A | LEU101 |
| A | ILE238 |
| A | PRO272 |
| A | GLY273 |
| A | GLY276 |
| A | VAL280 |
| A | NAP403 |
| A | HOH512 |
| A | HOH518 |
| A | HOH560 |
| site_id | AG2 |
| Number of Residues | 14 |
| Details | binding site for residues 21V A 402 and 21V A 403 |
| Chain | Residue |
| A | TYR52 |
| A | VAL55 |
| A | LYS56 |
| A | GLN100 |
| A | LEU101 |
| A | ILE238 |
| A | PRO272 |
| A | GLY273 |
| A | GLY276 |
| A | VAL280 |
| A | NAP403 |
| A | HOH512 |
| A | HOH518 |
| A | HOH560 |
| site_id | AG3 |
| Number of Residues | 14 |
| Details | binding site for residues 21V A 402 and 21V A 403 |
| Chain | Residue |
| A | TYR52 |
| A | VAL55 |
| A | LYS56 |
| A | GLN100 |
| A | LEU101 |
| A | ILE238 |
| A | PRO272 |
| A | GLY273 |
| A | GLY276 |
| A | VAL280 |
| A | NAP403 |
| A | HOH512 |
| A | HOH518 |
| A | HOH560 |
| site_id | AG4 |
| Number of Residues | 14 |
| Details | binding site for residues 21V A 402 and 21V A 403 |
| Chain | Residue |
| A | TYR52 |
| A | VAL55 |
| A | LYS56 |
| A | GLN100 |
| A | LEU101 |
| A | ILE238 |
| A | PRO272 |
| A | GLY273 |
| A | GLY276 |
| A | VAL280 |
| A | NAP403 |
| A | HOH512 |
| A | HOH518 |
| A | HOH560 |
| site_id | AG5 |
| Number of Residues | 14 |
| Details | binding site for residues 21V A 402 and 21V A 403 |
| Chain | Residue |
| A | TYR52 |
| A | VAL55 |
| A | LYS56 |
| A | GLN100 |
| A | LEU101 |
| A | ILE238 |
| A | PRO272 |
| A | GLY273 |
| A | GLY276 |
| A | VAL280 |
| A | NAP403 |
| A | HOH512 |
| A | HOH518 |
| A | HOH560 |
| site_id | AG6 |
| Number of Residues | 14 |
| Details | binding site for residues 21V A 402 and 21V A 403 |
| Chain | Residue |
| A | TYR52 |
| A | VAL55 |
| A | LYS56 |
| A | GLN100 |
| A | LEU101 |
| A | ILE238 |
| A | PRO272 |
| A | GLY273 |
| A | GLY276 |
| A | VAL280 |
| A | NAP403 |
| A | HOH512 |
| A | HOH518 |
| A | HOH560 |
| site_id | AG7 |
| Number of Residues | 14 |
| Details | binding site for residues 21V A 402 and 21V A 403 |
| Chain | Residue |
| A | TYR52 |
| A | VAL55 |
| A | LYS56 |
| A | GLN100 |
| A | LEU101 |
| A | ILE238 |
| A | PRO272 |
| A | GLY273 |
| A | GLY276 |
| A | VAL280 |
| A | NAP403 |
| A | HOH512 |
| A | HOH518 |
| A | HOH560 |
| site_id | AG8 |
| Number of Residues | 14 |
| Details | binding site for residues 21V A 402 and 21V A 403 |
| Chain | Residue |
| A | TYR52 |
| A | VAL55 |
| A | LYS56 |
| A | GLN100 |
| A | LEU101 |
| A | ILE238 |
| A | PRO272 |
| A | GLY273 |
| A | GLY276 |
| A | VAL280 |
| A | NAP403 |
| A | HOH512 |
| A | HOH518 |
| A | HOH560 |
| site_id | AG9 |
| Number of Residues | 14 |
| Details | binding site for residues 21V A 402 and 21V A 403 |
| Chain | Residue |
| A | TYR52 |
| A | VAL55 |
| A | LYS56 |
| A | GLN100 |
| A | LEU101 |
| A | ILE238 |
| A | PRO272 |
| A | GLY273 |
| A | GLY276 |
| A | VAL280 |
| A | NAP403 |
| A | HOH512 |
| A | HOH518 |
| A | HOH560 |
| site_id | AH1 |
| Number of Residues | 14 |
| Details | binding site for residues 21V A 402 and 21V A 403 |
| Chain | Residue |
| A | TYR52 |
| A | VAL55 |
| A | LYS56 |
| A | GLN100 |
| A | LEU101 |
| A | ILE238 |
| A | PRO272 |
| A | GLY273 |
| A | GLY276 |
| A | VAL280 |
| A | NAP403 |
| A | HOH512 |
| A | HOH518 |
| A | HOH560 |
| site_id | AH2 |
| Number of Residues | 14 |
| Details | binding site for residues 21V A 402 and 21V A 403 |
| Chain | Residue |
| A | TYR52 |
| A | VAL55 |
| A | LYS56 |
| A | GLN100 |
| A | LEU101 |
| A | ILE238 |
| A | PRO272 |
| A | GLY273 |
| A | GLY276 |
| A | VAL280 |
| A | NAP403 |
| A | HOH512 |
| A | HOH518 |
| A | HOH560 |
| site_id | AH3 |
| Number of Residues | 14 |
| Details | binding site for residues 21V A 402 and 21V A 403 |
| Chain | Residue |
| A | TYR52 |
| A | VAL55 |
| A | LYS56 |
| A | GLN100 |
| A | LEU101 |
| A | ILE238 |
| A | PRO272 |
| A | GLY273 |
| A | GLY276 |
| A | VAL280 |
| A | NAP403 |
| A | HOH512 |
| A | HOH518 |
| A | HOH560 |
| site_id | AH4 |
| Number of Residues | 14 |
| Details | binding site for residues 21V A 402 and 21V A 403 |
| Chain | Residue |
| A | TYR52 |
| A | VAL55 |
| A | LYS56 |
| A | GLN100 |
| A | LEU101 |
| A | ILE238 |
| A | PRO272 |
| A | GLY273 |
| A | GLY276 |
| A | VAL280 |
| A | NAP403 |
| A | HOH512 |
| A | HOH518 |
| A | HOH560 |
| site_id | AH5 |
| Number of Residues | 14 |
| Details | binding site for residues 21V A 402 and 21V A 403 |
| Chain | Residue |
| A | TYR52 |
| A | VAL55 |
| A | LYS56 |
| A | GLN100 |
| A | LEU101 |
| A | ILE238 |
| A | PRO272 |
| A | GLY273 |
| A | GLY276 |
| A | VAL280 |
| A | NAP403 |
| A | HOH512 |
| A | HOH518 |
| A | HOH560 |
| site_id | AH6 |
| Number of Residues | 14 |
| Details | binding site for residues 21V A 402 and 21V A 403 |
| Chain | Residue |
| A | TYR52 |
| A | VAL55 |
| A | LYS56 |
| A | GLN100 |
| A | LEU101 |
| A | ILE238 |
| A | PRO272 |
| A | GLY273 |
| A | GLY276 |
| A | VAL280 |
| A | NAP403 |
| A | HOH512 |
| A | HOH518 |
| A | HOH560 |
| site_id | AH7 |
| Number of Residues | 14 |
| Details | binding site for residues 21V A 402 and 21V A 403 |
| Chain | Residue |
| A | TYR52 |
| A | VAL55 |
| A | LYS56 |
| A | GLN100 |
| A | LEU101 |
| A | ILE238 |
| A | PRO272 |
| A | GLY273 |
| A | GLY276 |
| A | VAL280 |
| A | NAP403 |
| A | HOH512 |
| A | HOH518 |
| A | HOH560 |
| site_id | AH8 |
| Number of Residues | 14 |
| Details | binding site for residues 21V A 402 and 21V A 403 |
| Chain | Residue |
| A | TYR52 |
| A | VAL55 |
| A | LYS56 |
| A | GLN100 |
| A | LEU101 |
| A | ILE238 |
| A | PRO272 |
| A | GLY273 |
| A | GLY276 |
| A | VAL280 |
| A | NAP403 |
| A | HOH512 |
| A | HOH518 |
| A | HOH560 |
| site_id | AH9 |
| Number of Residues | 14 |
| Details | binding site for residues 21V A 402 and 21V A 403 |
| Chain | Residue |
| A | TYR52 |
| A | VAL55 |
| A | LYS56 |
| A | GLN100 |
| A | LEU101 |
| A | ILE238 |
| A | PRO272 |
| A | GLY273 |
| A | GLY276 |
| A | VAL280 |
| A | NAP403 |
| A | HOH512 |
| A | HOH518 |
| A | HOH560 |
| site_id | AI1 |
| Number of Residues | 14 |
| Details | binding site for residues 21V A 402 and 21V A 403 |
| Chain | Residue |
| A | TYR52 |
| A | VAL55 |
| A | LYS56 |
| A | GLN100 |
| A | LEU101 |
| A | ILE238 |
| A | PRO272 |
| A | GLY273 |
| A | GLY276 |
| A | VAL280 |
| A | NAP403 |
| A | HOH512 |
| A | HOH518 |
| A | HOH560 |
| site_id | AI2 |
| Number of Residues | 14 |
| Details | binding site for residues 21V A 402 and 21V A 403 |
| Chain | Residue |
| A | TYR52 |
| A | VAL55 |
| A | LYS56 |
| A | GLN100 |
| A | LEU101 |
| A | ILE238 |
| A | PRO272 |
| A | GLY273 |
| A | GLY276 |
| A | VAL280 |
| A | NAP403 |
| A | HOH512 |
| A | HOH518 |
| A | HOH560 |
| site_id | AI3 |
| Number of Residues | 14 |
| Details | binding site for residues 21V A 402 and 21V A 403 |
| Chain | Residue |
| A | TYR52 |
| A | VAL55 |
| A | LYS56 |
| A | GLN100 |
| A | LEU101 |
| A | ILE238 |
| A | PRO272 |
| A | GLY273 |
| A | GLY276 |
| A | VAL280 |
| A | NAP403 |
| A | HOH512 |
| A | HOH518 |
| A | HOH560 |
| site_id | AI4 |
| Number of Residues | 14 |
| Details | binding site for residues 21V A 402 and 21V A 403 |
| Chain | Residue |
| A | TYR52 |
| A | VAL55 |
| A | LYS56 |
| A | GLN100 |
| A | LEU101 |
| A | ILE238 |
| A | PRO272 |
| A | GLY273 |
| A | GLY276 |
| A | VAL280 |
| A | NAP403 |
| A | HOH512 |
| A | HOH518 |
| A | HOH560 |
Functional Information from PROSITE/UniProt
| site_id | PS00766 |
| Number of Residues | 26 |
| Details | THF_DHG_CYH_1 Tetrahydrofolate dehydrogenase/cyclohydrolase signature 1. EsEVMkyItsLNeDstvhgFLVQLPL |
| Chain | Residue | Details |
| A | GLU78-LEU103 | |
| site_id | PS00767 |
| Number of Residues | 9 |
| Details | THF_DHG_CYH_2 Tetrahydrofolate dehydrogenase/cyclohydrolase signature 2. PGGVGPMTV |
| Chain | Residue | Details |
| A | PRO272-VAL280 | |
Functional Information from SwissProt/UniProt
| Chain | Residue | Details |
| A | LYS56 | |
| B | LYS56 | |
| Chain | Residue | Details |
| A | TYR52 | |
| A | VAL99 | |
| A | PRO272 | |
| B | TYR52 | |
| B | VAL99 | |
| B | PRO272 | |
| Chain | Residue | Details |
| A | GLY172 | |
| A | SER197 | |
| B | GLY172 | |
| B | SER197 | |
| Chain | Residue | Details |
| A | MET1 | |
| B | MET1 | |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 3 |
| Details | M-CSA 389 |
| Chain | Residue | Details |
| A | LYS56 | activator |
| A | GLN100 | activator |
| A | ASP125 | electrostatic stabiliser |
| site_id | MCSA2 |
| Number of Residues | 3 |
| Details | M-CSA 458 |
| Chain | Residue | Details |
| A | SER49 | activator |
| A | LYS56 | proton shuttle (general acid/base) |
| A | GLN100 | activator |
| site_id | MCSA3 |
| Number of Residues | 3 |
| Details | M-CSA 389 |
| Chain | Residue | Details |
| B | LYS56 | activator |
| B | GLN100 | activator |
| B | ASP125 | electrostatic stabiliser |
| site_id | MCSA4 |
| Number of Residues | 3 |
| Details | M-CSA 458 |
| Chain | Residue | Details |
| B | SER49 | activator |
| B | LYS56 | proton shuttle (general acid/base) |
| B | GLN100 | activator |
