6EBS
Crystal structure of Leishmania major dihydroorotate dehydrogenase mutant H174A in complex with orotate
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Dihydroorotate dehydrogenase (fumarate) | polymer | 354 | 38092.5 | 2 | UniProt (Q4QEW7) Pfam (PF01180) In PDB | Leishmania major | Dihydroorotate oxidase |
2 | A, B | FLAVIN MONONUCLEOTIDE | non-polymer | 456.3 | 2 | Chemie (FMN) | |||
3 | A, B | OROTIC ACID | non-polymer | 156.1 | 2 | Chemie (ORO) | |||
4 | A, B | GLYCEROL | non-polymer | 92.1 | 4 | Chemie (GOL) | |||
5 | A, B | SULFATE ION | non-polymer | 96.1 | 6 | Chemie (SO4) | |||
6 | B | NICKEL (II) ION | non-polymer | 58.7 | 1 | Chemie (NI) | |||
7 | water | water | 18.0 | 496 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 320 (UniProt: Q4QEW7)
PDB | External Database | Details |
---|---|---|
Met -33 | - | initiating methionine |
Gly -32 | - | expression tag |
Ser -31 | - | expression tag |
Ser -30 | - | expression tag |
His -29 | - | expression tag |
His -28 | - | expression tag |
His -27 | - | expression tag |
His -26 | - | expression tag |
His -25 | - | expression tag |
His -24 | - | expression tag |
Ser -23 | - | expression tag |
Ser -22 | - | expression tag |
Gly -21 | - | expression tag |
Leu -20 | - | expression tag |
Val -19 | - | expression tag |
Pro -18 | - | expression tag |
Ala -17 | - | expression tag |
Gly -16 | - | expression tag |
Ser -15 | - | expression tag |
His -14 | - | expression tag |
Met -13 | - | expression tag |
Ala -12 | - | expression tag |
Ser -11 | - | expression tag |
Met -10 | - | expression tag |
Thr -9 | - | expression tag |
Gly -8 | - | expression tag |
Gly -7 | - | expression tag |
Gln -6 | - | expression tag |
Gln -5 | - | expression tag |
Met -4 | - | expression tag |
Gly -3 | - | expression tag |
Arg -2 | - | expression tag |
Gly -1 | - | expression tag |
Ser 0 | - | expression tag |
Ala 174 | His 174 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 76184.9 | |
Non-Polymers* | Number of molecules | 15 |
Total formula weight | 2228.3 | |
All* | Total formula weight | 78413.2 |