6EBS
Crystal structure of Leishmania major dihydroorotate dehydrogenase mutant H174A in complex with orotate
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000166 | molecular_function | nucleotide binding |
A | 0004152 | molecular_function | dihydroorotate dehydrogenase activity |
A | 0005654 | cellular_component | nucleoplasm |
A | 0005737 | cellular_component | cytoplasm |
A | 0006106 | biological_process | fumarate metabolic process |
A | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
A | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
A | 0006222 | biological_process | UMP biosynthetic process |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0016627 | molecular_function | oxidoreductase activity, acting on the CH-CH group of donors |
A | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
A | 0097014 | cellular_component | ciliary plasm |
A | 1990663 | molecular_function | dihydroorotate dehydrogenase (fumarate) activity |
B | 0000166 | molecular_function | nucleotide binding |
B | 0004152 | molecular_function | dihydroorotate dehydrogenase activity |
B | 0005654 | cellular_component | nucleoplasm |
B | 0005737 | cellular_component | cytoplasm |
B | 0006106 | biological_process | fumarate metabolic process |
B | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
B | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
B | 0006222 | biological_process | UMP biosynthetic process |
B | 0016491 | molecular_function | oxidoreductase activity |
B | 0016627 | molecular_function | oxidoreductase activity, acting on the CH-CH group of donors |
B | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
B | 0097014 | cellular_component | ciliary plasm |
B | 1990663 | molecular_function | dihydroorotate dehydrogenase (fumarate) activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 23 |
Details | binding site for residue FMN A 401 |
Chain | Residue |
A | ALA19 |
A | ASN195 |
A | GLY222 |
A | GLY223 |
A | VAL226 |
A | CYS249 |
A | GLY250 |
A | GLY251 |
A | GLY272 |
A | THR273 |
A | ORO402 |
A | ALA20 |
A | HOH510 |
A | HOH523 |
A | HOH539 |
A | HOH550 |
A | GLY21 |
A | LYS44 |
A | SER45 |
A | ASN68 |
A | ASN128 |
A | LYS165 |
A | ILE194 |
site_id | AC2 |
Number of Residues | 11 |
Details | binding site for residue ORO A 402 |
Chain | Residue |
A | LYS44 |
A | ASN68 |
A | MET70 |
A | GLY71 |
A | LEU72 |
A | ASN128 |
A | CYS131 |
A | ASN133 |
A | ASN195 |
A | SER196 |
A | FMN401 |
site_id | AC3 |
Number of Residues | 5 |
Details | binding site for residue GOL A 403 |
Chain | Residue |
A | ILE203 |
A | SO4408 |
A | HOH516 |
A | HOH613 |
B | LEU231 |
site_id | AC4 |
Number of Residues | 9 |
Details | binding site for residue GOL A 404 |
Chain | Residue |
A | ASP171 |
A | PHE172 |
A | ALA173 |
B | PRO132 |
B | LYS137 |
B | GLN139 |
B | ASN199 |
B | LYS215 |
B | HOH644 |
site_id | AC5 |
Number of Residues | 9 |
Details | binding site for residue GOL A 405 |
Chain | Residue |
A | PRO132 |
A | LYS137 |
A | PRO138 |
A | GLN139 |
A | ASN199 |
A | LYS215 |
B | ASP171 |
B | PHE172 |
B | ALA173 |
site_id | AC6 |
Number of Residues | 3 |
Details | binding site for residue SO4 A 406 |
Chain | Residue |
A | HIS160 |
A | SER161 |
A | HOH601 |
site_id | AC7 |
Number of Residues | 5 |
Details | binding site for residue SO4 A 407 |
Chain | Residue |
A | ARG239 |
A | THR311 |
A | HOH544 |
A | HOH629 |
A | HOH652 |
site_id | AC8 |
Number of Residues | 5 |
Details | binding site for residue SO4 A 408 |
Chain | Residue |
A | LEU62 |
A | PRO63 |
A | VAL202 |
A | GOL403 |
A | HOH649 |
site_id | AC9 |
Number of Residues | 23 |
Details | binding site for residue FMN B 401 |
Chain | Residue |
B | ALA19 |
B | ALA20 |
B | GLY21 |
B | LYS44 |
B | SER45 |
B | ASN68 |
B | ASN128 |
B | LYS165 |
B | ILE194 |
B | ASN195 |
B | GLY222 |
B | GLY223 |
B | VAL226 |
B | CYS249 |
B | GLY250 |
B | GLY251 |
B | GLY272 |
B | THR273 |
B | ORO402 |
B | HOH517 |
B | HOH536 |
B | HOH569 |
B | HOH580 |
site_id | AD1 |
Number of Residues | 12 |
Details | binding site for residue ORO B 402 |
Chain | Residue |
B | CYS131 |
B | PRO132 |
B | ASN133 |
B | ASN195 |
B | SER196 |
B | FMN401 |
B | LYS44 |
B | ASN68 |
B | MET70 |
B | GLY71 |
B | LEU72 |
B | ASN128 |
site_id | AD2 |
Number of Residues | 5 |
Details | binding site for residue GOL B 403 |
Chain | Residue |
A | LEU227 |
B | VAL202 |
B | ILE203 |
B | SO4406 |
B | HOH546 |
site_id | AD3 |
Number of Residues | 5 |
Details | binding site for residue SO4 B 404 |
Chain | Residue |
A | HOH504 |
B | ASN9 |
B | HIS160 |
B | SER161 |
B | HOH576 |
site_id | AD4 |
Number of Residues | 5 |
Details | binding site for residue SO4 B 405 |
Chain | Residue |
B | ARG239 |
B | THR311 |
B | HOH502 |
B | HOH520 |
B | HOH558 |
site_id | AD5 |
Number of Residues | 1 |
Details | binding site for residue SO4 B 406 |
Chain | Residue |
B | GOL403 |
site_id | AD6 |
Number of Residues | 2 |
Details | binding site for residue NI B 407 |
Chain | Residue |
B | TYR142 |
B | HOH590 |