6EBS
Crystal structure of Leishmania major dihydroorotate dehydrogenase mutant H174A in complex with orotate
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004152 | molecular_function | dihydroorotate dehydrogenase activity |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006106 | biological_process | fumarate metabolic process |
| A | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
| A | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
| A | 0006222 | biological_process | UMP biosynthetic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016627 | molecular_function | oxidoreductase activity, acting on the CH-CH group of donors |
| A | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
| A | 0097014 | cellular_component | ciliary plasm |
| A | 1990663 | molecular_function | dihydroorotate dehydrogenase (fumarate) activity |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0004152 | molecular_function | dihydroorotate dehydrogenase activity |
| B | 0005654 | cellular_component | nucleoplasm |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006106 | biological_process | fumarate metabolic process |
| B | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
| B | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
| B | 0006222 | biological_process | UMP biosynthetic process |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016627 | molecular_function | oxidoreductase activity, acting on the CH-CH group of donors |
| B | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
| B | 0097014 | cellular_component | ciliary plasm |
| B | 1990663 | molecular_function | dihydroorotate dehydrogenase (fumarate) activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 23 |
| Details | binding site for residue FMN A 401 |
| Chain | Residue |
| A | ALA19 |
| A | ASN195 |
| A | GLY222 |
| A | GLY223 |
| A | VAL226 |
| A | CYS249 |
| A | GLY250 |
| A | GLY251 |
| A | GLY272 |
| A | THR273 |
| A | ORO402 |
| A | ALA20 |
| A | HOH510 |
| A | HOH523 |
| A | HOH539 |
| A | HOH550 |
| A | GLY21 |
| A | LYS44 |
| A | SER45 |
| A | ASN68 |
| A | ASN128 |
| A | LYS165 |
| A | ILE194 |
| site_id | AC2 |
| Number of Residues | 11 |
| Details | binding site for residue ORO A 402 |
| Chain | Residue |
| A | LYS44 |
| A | ASN68 |
| A | MET70 |
| A | GLY71 |
| A | LEU72 |
| A | ASN128 |
| A | CYS131 |
| A | ASN133 |
| A | ASN195 |
| A | SER196 |
| A | FMN401 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue GOL A 403 |
| Chain | Residue |
| A | ILE203 |
| A | SO4408 |
| A | HOH516 |
| A | HOH613 |
| B | LEU231 |
| site_id | AC4 |
| Number of Residues | 9 |
| Details | binding site for residue GOL A 404 |
| Chain | Residue |
| A | ASP171 |
| A | PHE172 |
| A | ALA173 |
| B | PRO132 |
| B | LYS137 |
| B | GLN139 |
| B | ASN199 |
| B | LYS215 |
| B | HOH644 |
| site_id | AC5 |
| Number of Residues | 9 |
| Details | binding site for residue GOL A 405 |
| Chain | Residue |
| A | PRO132 |
| A | LYS137 |
| A | PRO138 |
| A | GLN139 |
| A | ASN199 |
| A | LYS215 |
| B | ASP171 |
| B | PHE172 |
| B | ALA173 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 A 406 |
| Chain | Residue |
| A | HIS160 |
| A | SER161 |
| A | HOH601 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 A 407 |
| Chain | Residue |
| A | ARG239 |
| A | THR311 |
| A | HOH544 |
| A | HOH629 |
| A | HOH652 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 A 408 |
| Chain | Residue |
| A | LEU62 |
| A | PRO63 |
| A | VAL202 |
| A | GOL403 |
| A | HOH649 |
| site_id | AC9 |
| Number of Residues | 23 |
| Details | binding site for residue FMN B 401 |
| Chain | Residue |
| B | ALA19 |
| B | ALA20 |
| B | GLY21 |
| B | LYS44 |
| B | SER45 |
| B | ASN68 |
| B | ASN128 |
| B | LYS165 |
| B | ILE194 |
| B | ASN195 |
| B | GLY222 |
| B | GLY223 |
| B | VAL226 |
| B | CYS249 |
| B | GLY250 |
| B | GLY251 |
| B | GLY272 |
| B | THR273 |
| B | ORO402 |
| B | HOH517 |
| B | HOH536 |
| B | HOH569 |
| B | HOH580 |
| site_id | AD1 |
| Number of Residues | 12 |
| Details | binding site for residue ORO B 402 |
| Chain | Residue |
| B | CYS131 |
| B | PRO132 |
| B | ASN133 |
| B | ASN195 |
| B | SER196 |
| B | FMN401 |
| B | LYS44 |
| B | ASN68 |
| B | MET70 |
| B | GLY71 |
| B | LEU72 |
| B | ASN128 |
| site_id | AD2 |
| Number of Residues | 5 |
| Details | binding site for residue GOL B 403 |
| Chain | Residue |
| A | LEU227 |
| B | VAL202 |
| B | ILE203 |
| B | SO4406 |
| B | HOH546 |
| site_id | AD3 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 B 404 |
| Chain | Residue |
| A | HOH504 |
| B | ASN9 |
| B | HIS160 |
| B | SER161 |
| B | HOH576 |
| site_id | AD4 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 B 405 |
| Chain | Residue |
| B | ARG239 |
| B | THR311 |
| B | HOH502 |
| B | HOH520 |
| B | HOH558 |
| site_id | AD5 |
| Number of Residues | 1 |
| Details | binding site for residue SO4 B 406 |
| Chain | Residue |
| B | GOL403 |
| site_id | AD6 |
| Number of Residues | 2 |
| Details | binding site for residue NI B 407 |
| Chain | Residue |
| B | TYR142 |
| B | HOH590 |
