6EBK

The voltage-activated Kv1.2-2.1 paddle chimera channel in lipid nanodiscs

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C, E, G (A, C, E, G)	Voltage-gated potassium channel subunit beta-2	polymer	333	37339.1	4	UniProt (P62483) Pfam (PF00248)	Rattus norvegicus (Rat)	K(+) channel subunit beta-2, Kv-beta-2
2	B, D, F, H (B, D, F, H)	Potassium voltage-gated channel subfamily A member 2,Potassium voltage-gated channel subfamily B member 2 chimera	polymer	513	58905.8	4	UniProt (P63142) UniProt (Q63099) Pfam (PF02214) Pfam (PF00520) Pfam (PF07885)	Rattus norvegicus (Rat)	RAK,RBK2,RCK5,Voltage-gated potassium channel subunit Kv1.2,CDRK,Voltage-gated potassium channel subunit Kv2.2,RAK,RBK2,RCK5,Voltage-gated potassium channel subunit Kv1.2
3	I, J, K, L (A, C, E, G)	NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE	non-polymer		743.4	4	Chemie (NAP)
4	M, N, O, P, Q... (A, B, C, D, E...)	water	water		18.0	128	Chemie (HOH)

Sequence modifications

A, C, E, G: 37 - 367 (UniProt: P62483)

PDB	External Database	Details
Met 35	-	expression tag
Val 36	-	expression tag

B, D, F, H: 1 - 266 (UniProt: P63142)

PDB	External Database	Details
Met -17	-	expression tag
Ala -16	-	expression tag
His -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
His -10	-	expression tag
His -9	-	expression tag
His -8	-	expression tag
Glu -7	-	expression tag
Asn -6	-	expression tag
Leu -5	-	expression tag
Tyr -4	-	expression tag
Phe -3	-	expression tag
Gln -2	-	expression tag
Gly -1	-	expression tag
Ser 0	-	expression tag
His 15	Leu 15	conflict
Gln 207	Asn 207	conflict

B, D, F, H: 267 - 298 (UniProt: Q63099)
B, D, F, H: 299 - 495 (UniProt: P63142)

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	384979.5
Non-Polymers*	Number of molecules	4
	Total formula weight	2973.6
All*	Total formula weight	387953.2

*Water molecules are not included.