Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6EBK

The voltage-activated Kv1.2-2.1 paddle chimera channel in lipid nanodiscs

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002244	biological_process	hematopoietic progenitor cell differentiation
A	0005249	molecular_function	voltage-gated potassium channel activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005856	cellular_component	cytoskeleton
A	0005874	cellular_component	microtubule
A	0005886	cellular_component	plasma membrane
A	0006811	biological_process	monoatomic ion transport
A	0006813	biological_process	potassium ion transport
A	0008076	cellular_component	voltage-gated potassium channel complex
A	0008106	molecular_function	alcohol dehydrogenase (NADP+) activity
A	0009898	cellular_component	cytoplasmic side of plasma membrane
A	0014069	cellular_component	postsynaptic density
A	0015459	molecular_function	potassium channel regulator activity
A	0016020	cellular_component	membrane
A	0016491	molecular_function	oxidoreductase activity
A	0030424	cellular_component	axon
A	0034705	cellular_component	potassium channel complex
A	0043005	cellular_component	neuron projection
A	0043194	cellular_component	axon initial segment
A	0043679	cellular_component	axon terminus
A	0044224	cellular_component	juxtaparanode region of axon
A	0044325	molecular_function	transmembrane transporter binding
A	0044877	molecular_function	protein-containing complex binding
A	0045202	cellular_component	synapse
A	0045445	biological_process	myoblast differentiation
A	0050905	biological_process	neuromuscular process
A	0055085	biological_process	transmembrane transport
A	0071805	biological_process	potassium ion transmembrane transport
A	0098839	cellular_component	postsynaptic density membrane
A	0098978	cellular_component	glutamatergic synapse
A	1901379	biological_process	regulation of potassium ion transmembrane transport
A	1990002	molecular_function	methylglyoxal reductase (NADPH) (acetol producing) activity
A	1990031	cellular_component	pinceau fiber
A	2000008	biological_process	regulation of protein localization to cell surface
B	0005216	molecular_function	monoatomic ion channel activity
B	0005249	molecular_function	voltage-gated potassium channel activity
B	0006811	biological_process	monoatomic ion transport
B	0006813	biological_process	potassium ion transport
B	0008076	cellular_component	voltage-gated potassium channel complex
B	0016020	cellular_component	membrane
B	0051260	biological_process	protein homooligomerization
B	0055085	biological_process	transmembrane transport
C	0002244	biological_process	hematopoietic progenitor cell differentiation
C	0005249	molecular_function	voltage-gated potassium channel activity
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0005856	cellular_component	cytoskeleton
C	0005874	cellular_component	microtubule
C	0005886	cellular_component	plasma membrane
C	0006811	biological_process	monoatomic ion transport
C	0006813	biological_process	potassium ion transport
C	0008076	cellular_component	voltage-gated potassium channel complex
C	0008106	molecular_function	alcohol dehydrogenase (NADP+) activity
C	0009898	cellular_component	cytoplasmic side of plasma membrane
C	0014069	cellular_component	postsynaptic density
C	0015459	molecular_function	potassium channel regulator activity
C	0016020	cellular_component	membrane
C	0016491	molecular_function	oxidoreductase activity
C	0030424	cellular_component	axon
C	0034705	cellular_component	potassium channel complex
C	0043005	cellular_component	neuron projection
C	0043194	cellular_component	axon initial segment
C	0043679	cellular_component	axon terminus
C	0044224	cellular_component	juxtaparanode region of axon
C	0044325	molecular_function	transmembrane transporter binding
C	0044877	molecular_function	protein-containing complex binding
C	0045202	cellular_component	synapse
C	0045445	biological_process	myoblast differentiation
C	0050905	biological_process	neuromuscular process
C	0055085	biological_process	transmembrane transport
C	0071805	biological_process	potassium ion transmembrane transport
C	0098839	cellular_component	postsynaptic density membrane
C	0098978	cellular_component	glutamatergic synapse
C	1901379	biological_process	regulation of potassium ion transmembrane transport
C	1990002	molecular_function	methylglyoxal reductase (NADPH) (acetol producing) activity
C	1990031	cellular_component	pinceau fiber
C	2000008	biological_process	regulation of protein localization to cell surface
D	0005216	molecular_function	monoatomic ion channel activity
D	0005249	molecular_function	voltage-gated potassium channel activity
D	0006811	biological_process	monoatomic ion transport
D	0006813	biological_process	potassium ion transport
D	0008076	cellular_component	voltage-gated potassium channel complex
D	0016020	cellular_component	membrane
D	0051260	biological_process	protein homooligomerization
D	0055085	biological_process	transmembrane transport
E	0002244	biological_process	hematopoietic progenitor cell differentiation
E	0005249	molecular_function	voltage-gated potassium channel activity
E	0005515	molecular_function	protein binding
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0005856	cellular_component	cytoskeleton
E	0005874	cellular_component	microtubule
E	0005886	cellular_component	plasma membrane
E	0006811	biological_process	monoatomic ion transport
E	0006813	biological_process	potassium ion transport
E	0008076	cellular_component	voltage-gated potassium channel complex
E	0008106	molecular_function	alcohol dehydrogenase (NADP+) activity
E	0009898	cellular_component	cytoplasmic side of plasma membrane
E	0014069	cellular_component	postsynaptic density
E	0015459	molecular_function	potassium channel regulator activity
E	0016020	cellular_component	membrane
E	0016491	molecular_function	oxidoreductase activity
E	0030424	cellular_component	axon
E	0034705	cellular_component	potassium channel complex
E	0043005	cellular_component	neuron projection
E	0043194	cellular_component	axon initial segment
E	0043679	cellular_component	axon terminus
E	0044224	cellular_component	juxtaparanode region of axon
E	0044325	molecular_function	transmembrane transporter binding
E	0044877	molecular_function	protein-containing complex binding
E	0045202	cellular_component	synapse
E	0045445	biological_process	myoblast differentiation
E	0050905	biological_process	neuromuscular process
E	0055085	biological_process	transmembrane transport
E	0071805	biological_process	potassium ion transmembrane transport
E	0098839	cellular_component	postsynaptic density membrane
E	0098978	cellular_component	glutamatergic synapse
E	1901379	biological_process	regulation of potassium ion transmembrane transport
E	1990002	molecular_function	methylglyoxal reductase (NADPH) (acetol producing) activity
E	1990031	cellular_component	pinceau fiber
E	2000008	biological_process	regulation of protein localization to cell surface
F	0005216	molecular_function	monoatomic ion channel activity
F	0005249	molecular_function	voltage-gated potassium channel activity
F	0006811	biological_process	monoatomic ion transport
F	0006813	biological_process	potassium ion transport
F	0008076	cellular_component	voltage-gated potassium channel complex
F	0016020	cellular_component	membrane
F	0051260	biological_process	protein homooligomerization
F	0055085	biological_process	transmembrane transport
G	0002244	biological_process	hematopoietic progenitor cell differentiation
G	0005249	molecular_function	voltage-gated potassium channel activity
G	0005515	molecular_function	protein binding
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0005856	cellular_component	cytoskeleton
G	0005874	cellular_component	microtubule
G	0005886	cellular_component	plasma membrane
G	0006811	biological_process	monoatomic ion transport
G	0006813	biological_process	potassium ion transport
G	0008076	cellular_component	voltage-gated potassium channel complex
G	0008106	molecular_function	alcohol dehydrogenase (NADP+) activity
G	0009898	cellular_component	cytoplasmic side of plasma membrane
G	0014069	cellular_component	postsynaptic density
G	0015459	molecular_function	potassium channel regulator activity
G	0016020	cellular_component	membrane
G	0016491	molecular_function	oxidoreductase activity
G	0030424	cellular_component	axon
G	0034705	cellular_component	potassium channel complex
G	0043005	cellular_component	neuron projection
G	0043194	cellular_component	axon initial segment
G	0043679	cellular_component	axon terminus
G	0044224	cellular_component	juxtaparanode region of axon
G	0044325	molecular_function	transmembrane transporter binding
G	0044877	molecular_function	protein-containing complex binding
G	0045202	cellular_component	synapse
G	0045445	biological_process	myoblast differentiation
G	0050905	biological_process	neuromuscular process
G	0055085	biological_process	transmembrane transport
G	0071805	biological_process	potassium ion transmembrane transport
G	0098839	cellular_component	postsynaptic density membrane
G	0098978	cellular_component	glutamatergic synapse
G	1901379	biological_process	regulation of potassium ion transmembrane transport
G	1990002	molecular_function	methylglyoxal reductase (NADPH) (acetol producing) activity
G	1990031	cellular_component	pinceau fiber
G	2000008	biological_process	regulation of protein localization to cell surface
H	0005216	molecular_function	monoatomic ion channel activity
H	0005249	molecular_function	voltage-gated potassium channel activity
H	0006811	biological_process	monoatomic ion transport
H	0006813	biological_process	potassium ion transport
H	0008076	cellular_component	voltage-gated potassium channel complex
H	0016020	cellular_component	membrane
H	0051260	biological_process	protein homooligomerization
H	0055085	biological_process	transmembrane transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	28
Details	binding site for residue NAP A 1001

Chain	Residue
A	GLY55
A	GLN214
A	TRP243
A	SER244
A	PRO245
A	LEU246
A	ALA247
A	CYS248
A	GLY249
A	LYS254
A	SER263
A	THR56
A	ARG264
A	PRO304
A	LEU321
A	LEU322
A	GLY323
A	SER325
A	GLN329
A	GLU332
A	ASN333
A	TRP57
A	ASP85
A	TYR90
A	LYS118
A	ASN158
A	SER188
A	ARG189

site_id	AC2
Number of Residues	29
Details	binding site for residue NAP C 1001

Chain	Residue
C	GLY55
C	THR56
C	TRP57
C	THR59
C	GLN63
C	TYR90
C	LYS118
C	ASN158
C	SER188
C	ARG189
C	GLN214
C	TRP243
C	SER244
C	PRO245
C	LEU246
C	ALA247
C	CYS248
C	GLY249
C	LYS254
C	TYR262
C	SER263
C	ARG264
C	PRO304
C	LEU322
C	GLY323
C	SER325
C	GLN329
C	GLU332
C	ASN333

site_id	AC3
Number of Residues	29
Details	binding site for residue NAP E 1001

Chain	Residue
E	GLY55
E	THR56
E	TRP57
E	THR59
E	GLN63
E	TYR90
E	LYS118
E	ASN158
E	SER188
E	ARG189
E	GLN214
E	TRP243
E	SER244
E	PRO245
E	LEU246
E	ALA247
E	CYS248
E	GLY249
E	LYS254
E	TYR262
E	SER263
E	ARG264
E	PRO304
E	LEU322
E	GLY323
E	SER325
E	GLN329
E	GLU332
E	ASN333

site_id	AC4
Number of Residues	29
Details	binding site for residue NAP G 1001

Chain	Residue
G	PRO245
G	LEU246
G	ALA247
G	CYS248
G	GLY249
G	LYS254
G	TYR262
G	SER263
G	ARG264
G	PRO304
G	LEU322
G	GLY323
G	SER325
G	GLN329
G	GLU332
G	ASN333
G	GLY55
G	THR56
G	TRP57
G	THR59
G	GLN63
G	TYR90
G	LYS118
G	ASN158
G	SER188
G	ARG189
G	GLN214
G	TRP243
G	SER244

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"PubMed","id":"18672894","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	56
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10399921","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10884227","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16002581","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18004376","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18806782","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20360102","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20534430","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23705070","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1EXB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1QRQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2A79","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2R9R","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3EAU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3EB3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3EB4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3LNM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3LUT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JTA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JTC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JTD","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"18004376","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20360102","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23705070","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2R9R","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3LNM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JTA","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10399921","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10884227","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16002581","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18004376","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18806782","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20360102","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20534430","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23705070","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1EXB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1QRQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2A79","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2R9R","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3EB3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3LNM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3LUT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JTA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JTC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JTD","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10399921","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10884227","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16002581","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18004376","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18806782","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20360102","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20534430","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23705070","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1EXB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1QRQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2R9R","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3EAU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3EB3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3EB4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3LNM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3LUT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JTA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JTC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JTD","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10399921","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10884227","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18004376","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18806782","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20360102","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23705070","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1EXB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1QRQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2R9R","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3EAU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3EB3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3EB4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3LNM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JTA","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10399921","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10884227","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16002581","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18004376","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18806782","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20360102","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20534430","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23705070","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1EXB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1QRQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2A79","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2R9R","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3EAU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3EB3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3EB4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3LNM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3LUT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JTA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JTD","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10399921","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23705070","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1QRQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JTC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JTD","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"23705070","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4JTC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JTD","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10399921","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10884227","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16002581","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18004376","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20360102","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20534430","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23705070","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1EXB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1QRQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2A79","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2R9R","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3LNM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3LUT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JTA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JTC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JTD","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"21357749","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	4
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q13303","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	84
Details	Transmembrane: {"description":"Helical; Name=Segment S1","evidences":[{"source":"UniProtKB","id":"P63142","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	152
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"18004376","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20360102","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20534430","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12151401","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	84
Details	Transmembrane: {"description":"Helical; Name=Segment S2","evidences":[{"source":"PubMed","id":"18004376","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20360102","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20534430","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI16
Number of Residues	96
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"UniProtKB","id":"P63142","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI17
Number of Residues	104
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"18004376","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20360102","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20534430","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI18
Number of Residues	84
Details	Transmembrane: {"description":"Helical; Name=Segment S5","evidences":[{"source":"PubMed","id":"18004376","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20360102","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20534430","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI19
Number of Residues	44
Details	Intramembrane: {"description":"Helical; Name=Pore helix","evidences":[{"source":"UniProtKB","id":"P63142","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI20
Number of Residues	28
Details	Intramembrane: {"evidences":[{"source":"UniProtKB","id":"P63142","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI21
Number of Residues	116
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"UniProtKB","id":"P63142","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI22
Number of Residues	112
Details	Transmembrane: {"description":"Helical; Name=Segment S6","evidences":[{"source":"UniProtKB","id":"P63142","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI23
Number of Residues	52
Details	Region: {"description":"S4-S5 linker","evidences":[{"source":"PubMed","id":"16002579","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI24
Number of Residues	20
Details	Motif: {"description":"Selectivity filter","evidences":[{"source":"UniProtKB","id":"P63142","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI25
Number of Residues	4
Details	Site: {"description":"Important for normal, slow channel gating","evidences":[{"source":"PubMed","id":"17766348","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI26
Number of Residues	4
Details	Site: {"description":"Important for binding with the scorpion mesomartoxin; when the scorpion mesomartoxin-rKv1.2/KCNA2 interaction is modeled, this residue is close to the 'Y-57' residue of the toxin","evidences":[{"source":"PubMed","id":"25514171","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI27
Number of Residues	4
Details	Lipidation: {"description":"S-palmitoyl cysteine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI28
Number of Residues	4
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"16770729","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI29
Number of Residues	72
Details	Transmembrane: {"description":"Helical; Name=Segment S3","evidences":[{"source":"UniProtKB","id":"P63142","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI30
Number of Residues	80
Details	Transmembrane: {"description":"Helical; Voltage-sensor; Name=Segment S4","evidences":[{"source":"UniProtKB","id":"P63142","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI31
Number of Residues	88
Details	Transmembrane: {"description":"Helical; Name=Segment S5","evidences":[{"source":"UniProtKB","id":"P63142","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI32
Number of Residues	4
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)