6EAY
Structural Basis for Broad Neutralization of Ebolaviruses by an Antibody Targeting the Glycoprotein Fusion Loop
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (L) | CA45 light chain | polymer | 215 | 23291.8 | 1 | Macaca fascicularis | ||
| 2 | B (H) | CA45 heavy chain | polymer | 237 | 25169.2 | 1 | Macaca fascicularis | ||
| 3 | C (A) | Envelope glycoprotein | polymer | 163 | 18636.9 | 1 | UniProt (Q05320) Pfam (PF22307) | Zaire ebolavirus (strain Mayinga-76) (ZEBOV) | GP1,2,GP |
| 4 | D (B) | Envelope glycoprotein | polymer | 319 | 35319.6 | 1 | UniProt (Q05320) Pfam (PF01611) | Zaire ebolavirus (strain Mayinga-76) (ZEBOV) | GP1,2,GP |
| 5 | E (C) | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1397.2 | 1 | In PDB GlyTouCan (G80966KZ) | |||
| 6 | F, G (B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) |
Sequence modifications
A: 502 - 637 (UniProt: Q05320)
B: 32 - 311 (UniProt: Q05320)
B: 312 - 350 (UniProt: Q05320)
| PDB | External Database | Details |
|---|---|---|
| Thr 544 | Ile 544 | conflict |
| Gly 638 | - | expression tag |
| Glu 639 | - | expression tag |
| Asn 640 | - | expression tag |
| Leu 641 | - | expression tag |
| Tyr 642 | - | expression tag |
| Phe 643 | - | expression tag |
| Gln 644 | - | expression tag |
| Ser 645 | - | expression tag |
| Gly 646 | - | expression tag |
| Ser 647 | - | expression tag |
| Ala 648 | - | expression tag |
| Trp 649 | - | expression tag |
| Ser 650 | - | expression tag |
| His 651 | - | expression tag |
| Pro 652 | - | expression tag |
| Gln 653 | - | expression tag |
| Phe 654 | - | expression tag |
| Glu 655 | - | expression tag |
| Lys 656 | - | expression tag |
| His 657 | - | expression tag |
| His 658 | - | expression tag |
| His 659 | - | expression tag |
| His 660 | - | expression tag |
| His 661 | - | expression tag |
| His 662 | - | expression tag |
| His 663 | - | expression tag |
| His 664 | - | expression tag |
B: 312 - 350 (UniProt: Q05320)
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 102417.4 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 1397.2 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 442.4 | |
| All* | Total formula weight | 104257.1 |
