6EAY

Structural Basis for Broad Neutralization of Ebolaviruses by an Antibody Targeting the Glycoprotein Fusion Loop

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	L	CA45 light chain	polymer	215	23291.8	1		Macaca fascicularis
2	H	CA45 heavy chain	polymer	237	25169.2	1		Macaca fascicularis
3	A	Envelope glycoprotein	polymer	163	18636.9	1	UniProt (Q05320) Pfam (PF22307) In PDB	Zaire ebolavirus (strain Mayinga-76) (ZEBOV)	GP1,2,GP
4	B	Envelope glycoprotein	polymer	319	35319.6	1	UniProt (Q05320) Pfam (PF01611) In PDB	Zaire ebolavirus (strain Mayinga-76) (ZEBOV)	GP1,2,GP
5	C	alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		1397.2	1	In PDB GlyTouCan (G80966KZ)
6	B	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	2	Chemie (NAG)

Sequence modifications

A: 502 - 637 (UniProt: Q05320)

PDB	External Database	Details
Thr 544	Ile 544	conflict
Gly 638	-	expression tag
Glu 639	-	expression tag
Asn 640	-	expression tag
Leu 641	-	expression tag
Tyr 642	-	expression tag
Phe 643	-	expression tag
Gln 644	-	expression tag
Ser 645	-	expression tag
Gly 646	-	expression tag
Ser 647	-	expression tag
Ala 648	-	expression tag
Trp 649	-	expression tag
Ser 650	-	expression tag
His 651	-	expression tag
Pro 652	-	expression tag
Gln 653	-	expression tag
Phe 654	-	expression tag
Glu 655	-	expression tag
Lys 656	-	expression tag
His 657	-	expression tag
His 658	-	expression tag
His 659	-	expression tag
His 660	-	expression tag
His 661	-	expression tag
His 662	-	expression tag
His 663	-	expression tag
His 664	-	expression tag

B: 32 - 311 (UniProt: Q05320)
B: 312 - 350 (UniProt: Q05320)

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	102417.4
Branched	Number of molecules	1
	Total formula weight	1397.2
Non-Polymers*	Number of molecules	2
	Total formula weight	442.4
All*	Total formula weight	104257.1

*Water molecules are not included.