6E9P
Crystal structure of tryptophan synthase from M. tuberculosis - open form with BRD0059 bound
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C, E, G (A, C, E, G) | Tryptophan synthase alpha chain | polymer | 276 | 28579.4 | 4 | UniProt (P9WFY1) Pfam (PF00290) | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) | |
| 2 | B, D, F, H (B, D, F, H) | Tryptophan synthase beta chain | polymer | 410 | 43562.7 | 4 | UniProt (P9WFX9) Pfam (PF00291) | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) | |
| 3 | I, W (A, C) | MALONIC ACID | non-polymer | 104.1 | 2 | Chemie (MLA) | |||
| 4 | BB, J, O, Q, ZA (G, A, B) | ACETATE ION | non-polymer | 59.0 | 5 | Chemie (ACT) | |||
| 5 | AB, HA, HB, IA, IB... (G, D, H, A, E...) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 13 | Chemie (EDO) | |||
| 6 | AA, CB, L, RA (D, H, B, F) | (2R,3S,4R)-3-(2',6'-difluoro-4'-methyl[1,1'-biphenyl]-4-yl)-4-(fluoromethyl)azetidine-2-carbonitrile | non-polymer | 316.3 | 4 | Chemie (HDJ) | |||
| 7 | M (B) | D-MALATE | non-polymer | 134.1 | 1 | Chemie (MLT) | |||
| 8 | BA, CA, DA, DB, EA... (D, H, B, F, C) | FORMIC ACID | non-polymer | 46.0 | 29 | Chemie (FMT) | |||
| 9 | KB, LB, MB, NB, OB... (A, B, C, D, E...) | water | water | 18.0 | 222 | Chemie (HOH) |
Sequence modifications
A, C, E, G: 1 - 270 (UniProt: P9WFY1)
| PDB | External Database | Details |
|---|---|---|
| His 271 | - | expression tag |
| His 272 | - | expression tag |
| His 273 | - | expression tag |
| His 274 | - | expression tag |
| His 275 | - | expression tag |
| His 276 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 288568.6 | |
| Non-Polymers* | Number of molecules | 54 |
| Total formula weight | 4044.3 | |
| All* | Total formula weight | 292613.0 |
