6E9P
Crystal structure of tryptophan synthase from M. tuberculosis - open form with BRD0059 bound
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000162 | biological_process | L-tryptophan biosynthetic process |
| A | 0004834 | molecular_function | tryptophan synthase activity |
| A | 0005829 | cellular_component | cytosol |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006568 | biological_process | L-tryptophan metabolic process |
| A | 0008652 | biological_process | amino acid biosynthetic process |
| A | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| A | 0016829 | molecular_function | lyase activity |
| B | 0000162 | biological_process | L-tryptophan biosynthetic process |
| B | 0004834 | molecular_function | tryptophan synthase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006568 | biological_process | L-tryptophan metabolic process |
| B | 0008652 | biological_process | amino acid biosynthetic process |
| B | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| B | 0016829 | molecular_function | lyase activity |
| B | 1901605 | biological_process | alpha-amino acid metabolic process |
| C | 0000162 | biological_process | L-tryptophan biosynthetic process |
| C | 0004834 | molecular_function | tryptophan synthase activity |
| C | 0005829 | cellular_component | cytosol |
| C | 0005886 | cellular_component | plasma membrane |
| C | 0006568 | biological_process | L-tryptophan metabolic process |
| C | 0008652 | biological_process | amino acid biosynthetic process |
| C | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| C | 0016829 | molecular_function | lyase activity |
| D | 0000162 | biological_process | L-tryptophan biosynthetic process |
| D | 0004834 | molecular_function | tryptophan synthase activity |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0006568 | biological_process | L-tryptophan metabolic process |
| D | 0008652 | biological_process | amino acid biosynthetic process |
| D | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| D | 0016829 | molecular_function | lyase activity |
| D | 1901605 | biological_process | alpha-amino acid metabolic process |
| E | 0000162 | biological_process | L-tryptophan biosynthetic process |
| E | 0004834 | molecular_function | tryptophan synthase activity |
| E | 0005829 | cellular_component | cytosol |
| E | 0005886 | cellular_component | plasma membrane |
| E | 0006568 | biological_process | L-tryptophan metabolic process |
| E | 0008652 | biological_process | amino acid biosynthetic process |
| E | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| E | 0016829 | molecular_function | lyase activity |
| F | 0000162 | biological_process | L-tryptophan biosynthetic process |
| F | 0004834 | molecular_function | tryptophan synthase activity |
| F | 0005737 | cellular_component | cytoplasm |
| F | 0006568 | biological_process | L-tryptophan metabolic process |
| F | 0008652 | biological_process | amino acid biosynthetic process |
| F | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| F | 0016829 | molecular_function | lyase activity |
| F | 1901605 | biological_process | alpha-amino acid metabolic process |
| G | 0000162 | biological_process | L-tryptophan biosynthetic process |
| G | 0004834 | molecular_function | tryptophan synthase activity |
| G | 0005829 | cellular_component | cytosol |
| G | 0005886 | cellular_component | plasma membrane |
| G | 0006568 | biological_process | L-tryptophan metabolic process |
| G | 0008652 | biological_process | amino acid biosynthetic process |
| G | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| G | 0016829 | molecular_function | lyase activity |
| H | 0000162 | biological_process | L-tryptophan biosynthetic process |
| H | 0004834 | molecular_function | tryptophan synthase activity |
| H | 0005737 | cellular_component | cytoplasm |
| H | 0006568 | biological_process | L-tryptophan metabolic process |
| H | 0008652 | biological_process | amino acid biosynthetic process |
| H | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| H | 0016829 | molecular_function | lyase activity |
| H | 1901605 | biological_process | alpha-amino acid metabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | binding site for residue MLA A 501 |
| Chain | Residue |
| A | TYR181 |
| A | GLY217 |
| A | LEU218 |
| A | GLY219 |
| A | GLY239 |
| A | SER240 |
| A | HOH602 |
| A | HOH609 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue ACT A 502 |
| Chain | Residue |
| A | PRO70 |
| A | THR71 |
| A | SER240 |
| A | HOH605 |
| A | GLY69 |
| site_id | AC3 |
| Number of Residues | 9 |
| Details | binding site for residue EDO A 503 |
| Chain | Residue |
| A | TYR30 |
| A | VAL60 |
| A | PRO61 |
| A | TYR62 |
| A | PRO65 |
| A | ASP68 |
| A | THR76 |
| A | MET106 |
| A | TYR108 |
| site_id | AC4 |
| Number of Residues | 13 |
| Details | binding site for residue HDJ B 501 |
| Chain | Residue |
| A | ASP64 |
| A | GLY66 |
| A | MET67 |
| A | TYR108 |
| B | LEU34 |
| B | ILE184 |
| B | ASN185 |
| B | PHE188 |
| B | PHE202 |
| B | PRO208 |
| B | PHE211 |
| B | HIS294 |
| B | GLY295 |
| site_id | AC5 |
| Number of Residues | 10 |
| Details | binding site for residue MLT B 502 |
| Chain | Residue |
| B | ASP57 |
| B | ARG60 |
| B | LEU61 |
| B | LEU110 |
| B | ARG113 |
| B | LEU140 |
| B | HOH601 |
| B | HOH633 |
| F | GLN231 |
| F | GLY232 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | binding site for residue FMT B 503 |
| Chain | Residue |
| B | GLY351 |
| B | ARG355 |
| H | LEU165 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | binding site for residue ACT B 504 |
| Chain | Residue |
| B | HIS11 |
| B | ASP12 |
| B | GLY20 |
| B | TRP329 |
| G | GLN231 |
| site_id | AC8 |
| Number of Residues | 7 |
| Details | binding site for residue FMT B 505 |
| Chain | Residue |
| B | GLU74 |
| B | ALA75 |
| B | THR76 |
| B | SER79 |
| B | ALA85 |
| B | ARG86 |
| B | ILE87 |
| site_id | AC9 |
| Number of Residues | 3 |
| Details | binding site for residue ACT B 506 |
| Chain | Residue |
| B | LEU237 |
| B | PRO238 |
| B | GLY263 |
| site_id | AD1 |
| Number of Residues | 3 |
| Details | binding site for residue FMT B 507 |
| Chain | Residue |
| A | GLN144 |
| B | SER23 |
| B | PHE297 |
| site_id | AD2 |
| Number of Residues | 6 |
| Details | binding site for residue FMT B 508 |
| Chain | Residue |
| B | VAL245 |
| B | GLY246 |
| B | ALA282 |
| B | THR284 |
| B | TYR320 |
| B | GLY322 |
| site_id | AD3 |
| Number of Residues | 2 |
| Details | binding site for residue FMT B 509 |
| Chain | Residue |
| B | GLU48 |
| B | ARG114 |
| site_id | AD4 |
| Number of Residues | 3 |
| Details | binding site for residue FMT B 510 |
| Chain | Residue |
| B | HIS11 |
| B | GLU326 |
| B | TRP329 |
| site_id | AD5 |
| Number of Residues | 3 |
| Details | binding site for residue EDO B 511 |
| Chain | Residue |
| B | PRO262 |
| B | GLY263 |
| B | ARG265 |
| site_id | AD6 |
| Number of Residues | 8 |
| Details | binding site for residue MLA C 501 |
| Chain | Residue |
| C | TYR181 |
| C | GLY217 |
| C | LEU218 |
| C | GLY219 |
| C | GLY239 |
| C | SER240 |
| C | HOH604 |
| C | HOH607 |
| site_id | AD7 |
| Number of Residues | 4 |
| Details | binding site for residue FMT C 502 |
| Chain | Residue |
| C | GLY116 |
| C | VAL117 |
| C | ASP118 |
| C | ALA119 |
| site_id | AD8 |
| Number of Residues | 3 |
| Details | binding site for residue FMT C 503 |
| Chain | Residue |
| C | PRO39 |
| C | VAL42 |
| C | ALA43 |
| site_id | AD9 |
| Number of Residues | 3 |
| Details | binding site for residue FMT C 504 |
| Chain | Residue |
| C | LEU113 |
| C | GLN144 |
| D | SER23 |
| site_id | AE1 |
| Number of Residues | 11 |
| Details | binding site for residue HDJ D 501 |
| Chain | Residue |
| C | MET67 |
| D | LEU34 |
| D | ILE184 |
| D | ASN185 |
| D | PHE188 |
| D | PHE202 |
| D | PRO208 |
| D | PHE211 |
| D | HIS294 |
| D | GLY295 |
| C | ASP64 |
| site_id | AE2 |
| Number of Residues | 1 |
| Details | binding site for residue FMT D 502 |
| Chain | Residue |
| D | ARG335 |
| site_id | AE3 |
| Number of Residues | 3 |
| Details | binding site for residue FMT D 503 |
| Chain | Residue |
| B | LYS402 |
| B | GLY405 |
| D | TRP403 |
| site_id | AE4 |
| Number of Residues | 3 |
| Details | binding site for residue FMT D 504 |
| Chain | Residue |
| D | HIS11 |
| D | ASP12 |
| D | GLY20 |
| site_id | AE5 |
| Number of Residues | 2 |
| Details | binding site for residue FMT D 505 |
| Chain | Residue |
| B | ARG60 |
| D | ASN64 |
| site_id | AE6 |
| Number of Residues | 1 |
| Details | binding site for residue FMT D 506 |
| Chain | Residue |
| H | ASN194 |
| site_id | AE7 |
| Number of Residues | 5 |
| Details | binding site for residue FMT D 507 |
| Chain | Residue |
| D | ARG265 |
| D | LEU266 |
| D | ARG335 |
| D | ASP337 |
| D | EDO510 |
| site_id | AE8 |
| Number of Residues | 3 |
| Details | binding site for residue EDO D 508 |
| Chain | Residue |
| B | TRP403 |
| B | HOH611 |
| D | LYS402 |
| site_id | AE9 |
| Number of Residues | 6 |
| Details | binding site for residue EDO D 509 |
| Chain | Residue |
| D | THR124 |
| D | GLY125 |
| D | ALA126 |
| D | GLY127 |
| D | GLN128 |
| D | HIS129 |
| site_id | AF1 |
| Number of Residues | 4 |
| Details | binding site for residue EDO D 510 |
| Chain | Residue |
| D | PRO262 |
| D | GLY263 |
| D | ARG265 |
| D | FMT507 |
| site_id | AF2 |
| Number of Residues | 4 |
| Details | binding site for residue EDO D 511 |
| Chain | Residue |
| B | GLY273 |
| B | THR342 |
| B | SER344 |
| D | ASN409 |
| site_id | AF3 |
| Number of Residues | 7 |
| Details | binding site for residue FMT D 512 |
| Chain | Residue |
| D | GLY291 |
| D | PHE293 |
| D | SER296 |
| D | SER298 |
| D | TYR299 |
| D | GLY322 |
| D | VAL323 |
| site_id | AF4 |
| Number of Residues | 4 |
| Details | binding site for residue FMT D 513 |
| Chain | Residue |
| D | ALA44 |
| D | LYS47 |
| D | GLU48 |
| D | ARG114 |
| site_id | AF5 |
| Number of Residues | 3 |
| Details | binding site for residue FMT D 514 |
| Chain | Residue |
| D | SER23 |
| D | GLY24 |
| D | GLU332 |
| site_id | AF6 |
| Number of Residues | 5 |
| Details | binding site for residue FMT D 515 |
| Chain | Residue |
| D | TYR73 |
| D | THR76 |
| D | ARG77 |
| D | GLU357 |
| F | LEU139 |
| site_id | AF7 |
| Number of Residues | 7 |
| Details | binding site for residue FMT D 516 |
| Chain | Residue |
| D | VAL245 |
| D | GLY246 |
| D | GLU270 |
| D | ALA282 |
| D | THR284 |
| D | TYR320 |
| D | GLY322 |
| site_id | AF8 |
| Number of Residues | 4 |
| Details | binding site for residue EDO E 501 |
| Chain | Residue |
| E | TYR181 |
| E | GLY217 |
| E | GLY239 |
| E | SER240 |
| site_id | AF9 |
| Number of Residues | 12 |
| Details | binding site for residue HDJ F 501 |
| Chain | Residue |
| E | ASP64 |
| E | GLY66 |
| E | MET67 |
| F | LEU34 |
| F | ILE184 |
| F | ASN185 |
| F | PHE188 |
| F | PHE202 |
| F | PRO208 |
| F | PHE211 |
| F | HIS294 |
| F | GLY295 |
| site_id | AG1 |
| Number of Residues | 1 |
| Details | binding site for residue FMT F 502 |
| Chain | Residue |
| F | SER23 |
| site_id | AG2 |
| Number of Residues | 2 |
| Details | binding site for residue FMT F 504 |
| Chain | Residue |
| F | VAL160 |
| F | VAL170 |
| site_id | AG3 |
| Number of Residues | 4 |
| Details | binding site for residue FMT F 505 |
| Chain | Residue |
| F | GLU345 |
| F | ALA349 |
| F | ALA370 |
| F | LEU373 |
| site_id | AG4 |
| Number of Residues | 2 |
| Details | binding site for residue EDO F 506 |
| Chain | Residue |
| F | PRO262 |
| F | ARG265 |
| site_id | AG5 |
| Number of Residues | 5 |
| Details | binding site for residue EDO F 507 |
| Chain | Residue |
| D | LEU139 |
| F | TYR73 |
| F | THR76 |
| F | ARG77 |
| F | GLU357 |
| site_id | AG6 |
| Number of Residues | 5 |
| Details | binding site for residue EDO F 508 |
| Chain | Residue |
| F | ARG236 |
| H | SER79 |
| H | GLN80 |
| H | SER84 |
| H | ARG381 |
| site_id | AG7 |
| Number of Residues | 4 |
| Details | binding site for residue ACT G 501 |
| Chain | Residue |
| G | MET67 |
| G | ASP68 |
| G | MET106 |
| G | TYR181 |
| site_id | AG8 |
| Number of Residues | 5 |
| Details | binding site for residue EDO G 502 |
| Chain | Residue |
| G | TYR181 |
| G | THR185 |
| G | GLY217 |
| G | GLY239 |
| G | SER240 |
| site_id | AG9 |
| Number of Residues | 2 |
| Details | binding site for residue ACT G 503 |
| Chain | Residue |
| G | GLN144 |
| H | SER23 |
| site_id | AH1 |
| Number of Residues | 14 |
| Details | binding site for residue HDJ H 501 |
| Chain | Residue |
| G | ASP64 |
| G | GLY66 |
| G | MET67 |
| G | TYR108 |
| G | ASP136 |
| H | LEU34 |
| H | ILE184 |
| H | ASN185 |
| H | PHE188 |
| H | PHE202 |
| H | PRO208 |
| H | PHE211 |
| H | HIS294 |
| H | GLY295 |
| site_id | AH2 |
| Number of Residues | 3 |
| Details | binding site for residue FMT H 502 |
| Chain | Residue |
| H | PRO238 |
| H | ASP239 |
| H | GLY263 |
| site_id | AH3 |
| Number of Residues | 1 |
| Details | binding site for residue FMT H 503 |
| Chain | Residue |
| H | ASP217 |
| site_id | AH4 |
| Number of Residues | 3 |
| Details | binding site for residue FMT H 504 |
| Chain | Residue |
| H | LYS47 |
| H | GLU48 |
| H | ARG114 |
| site_id | AH5 |
| Number of Residues | 6 |
| Details | binding site for residue FMT H 505 |
| Chain | Residue |
| B | PRO69 |
| B | PRO71 |
| D | GLN52 |
| H | ALA63 |
| H | GLY67 |
| H | ARG68 |
| site_id | AH6 |
| Number of Residues | 4 |
| Details | binding site for residue EDO H 506 |
| Chain | Residue |
| H | GLN128 |
| H | ASN159 |
| H | ARG162 |
| H | LYS395 |
| site_id | AH7 |
| Number of Residues | 3 |
| Details | binding site for residue EDO H 507 |
| Chain | Residue |
| H | PRO262 |
| H | GLY263 |
| H | ARG265 |
| site_id | AH8 |
| Number of Residues | 3 |
| Details | binding site for residue FMT H 508 |
| Chain | Residue |
| H | ALA36 |
| H | GLU40 |
| H | ALA195 |
Functional Information from PROSITE/UniProt
| site_id | PS00167 |
| Number of Residues | 14 |
| Details | TRP_SYNTHASE_ALPHA Tryptophan synthase alpha chain signature. IEVGvPYSDPGMDG |
| Chain | Residue | Details |
| A | ILE56-GLY69 |
| site_id | PS00168 |
| Number of Residues | 15 |
| Details | TRP_SYNTHASE_BETA Tryptophan synthase beta chain pyridoxal-phosphate attachment site. LnHtGSHKiNnvLgQ |
| Chain | Residue | Details |
| B | LEU94-GLN108 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | MOD_RES: N6-(pyridoxal phosphate)lysine => ECO:0000255|HAMAP-Rule:MF_00133 |
| Chain | Residue | Details |
| B | HIS100 | |
| D | HIS100 | |
| F | HIS100 | |
| H | HIS100 | |
| E | GLU57 | |
| E | ASP68 | |
| G | GLU57 | |
| G | ASP68 |
