6E7F

Crystal Structure of Human Inositol Polyphosphate Multikinase (IPMK) Catalytic Core Domain

Replaces:  6C8A

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Inositol polyphosphate multikinase	polymer	278	31866.1	2	UniProt (Q8NFU5) Pfam (PF03770)	Homo sapiens (Human)	Inositol 1,3,4,6-tetrakisphosphate 5-kinase,Inositol 1,3,4,6-tetrakisphosphate 5-kinase
2	C, D, E (A, B)	SULFATE ION	non-polymer		96.1	3	Chemie (SO4)
3	F, G (A, B)	water	water		18.0	72	Chemie (HOH)

Sequence modifications

A, B: 70 - 363 (UniProt: Q8NFU5)

PDB	External Database	Details
Met -17	-	expression tag
His -16	-	expression tag
His -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
Glu 62	-	expression tag
Asn 63	-	expression tag
Leu 64	-	expression tag
Tyr 65	-	expression tag
Phe 66	-	expression tag
Gln 67	-	expression tag
Gly 68	-	expression tag
Met 69	-	expression tag

A, B: 374 - 416 (UniProt: Q8NFU5)

PDB	External Database	Details
Gly 364	-	linker
Gly 365	-	linker
Gly 366	-	linker
Gly 367	-	linker
Ser 368	-	linker
Gly 369	-	linker
Gly 370	-	linker
Gly 371	-	linker
Gly 372	-	linker
Ser 373	-	linker

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	63732.2
Non-Polymers*	Number of molecules	3
	Total formula weight	288.2
All*	Total formula weight	64020.4

*Water molecules are not included.