6E5V

human mGlu8 receptor amino terminal domain in complex with (S)-3,4-Dicarboxyphenylglycine (DCPG)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Metabotropic glutamate receptor 8	polymer	523	58832.7	2	UniProt (O00222) Pfam (PF01094)	Homo sapiens (Human)	mGluR8
2	C, E (A, B)	4-[(S)-amino(carboxy)methyl]benzene-1,2-dicarboxylic acid	non-polymer		239.2	2	Chemie (HVG)
3	D, F (A, B)	CHLORIDE ION	non-polymer		35.5	2	Chemie (CL)
4	G, H (A, B)	water	water		18.0	36	Chemie (HOH)

Sequence modifications

A, B: 3 - 508 (UniProt: O00222)

PDB	External Database	Details
Met 0	-	initiating methionine
Ala 1	-	expression tag
Leu 2	-	expression tag
-	Gln 29	deletion
Ser 246	Cys 246	engineered mutation
Asn 509	-	expression tag
Leu 510	-	expression tag
Tyr 511	-	expression tag
Phe 512	-	expression tag
Gln 513	-	expression tag
Gly 514	-	expression tag
Glu 515	-	expression tag
Gly 516	-	expression tag
His 517	-	expression tag
His 518	-	expression tag
His 519	-	expression tag
His 520	-	expression tag
His 521	-	expression tag
His 522	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	117665.4
Non-Polymers*	Number of molecules	4
	Total formula weight	549.3
All*	Total formula weight	118214.7

*Water molecules are not included.