6DZL

Ebola virus Makona variant GP (mucin-deleted) in complex with pan-ebolavirus human antibody ADI-15878 Fab

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C	Ebola virus Makona GP1	polymer	321	35517.8	3	UniProt (A0A0F7IM40) Pfam (PF01611) UniProt (by SIFTS) (P87666) In PDB	Zaire ebolavirus (ZEBOV)
2	D, E, F	Ebola virus Makona GP2	polymer	166	18334.4	3	UniProt (P87666) Pfam (PF22307) In PDB	Zaire ebolavirus (ZEBOV)	GP1,2,GP
3	J, K, L	Fv domain of ADI-15878 Fab light chain	polymer	106	11333.5	3		Homo sapiens
4	G, H, I	Fv domain of ADI-15878 Fab heavy chain	polymer	121	13171.7	3		Homo sapiens
5	M, O, Q	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	3	In PDB GlyTouCan (G42666HT)
6	N, P, R	alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		1073.0	3	In PDB GlyTouCan (G56014GC)
7	A, B, C	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	6	Chemie (NAG)

Sequence modifications

A, B, C: 32 - 311 (UniProt: A0A0F7IM40)

PDB	External Database	Details
Asn 312	-	expression tag
Asn 313	-	expression tag
Asn 314	-	expression tag
Thr 315	-	expression tag
His 316	-	expression tag
His 317	-	expression tag
Gln 318	-	expression tag
Asp 319	-	expression tag
Thr 320	-	expression tag
Gly 321	-	expression tag
Glu 322	-	expression tag
Glu 323	-	expression tag
Ser 324	-	expression tag
Ala 325	-	expression tag
Ser 326	-	expression tag
Ser 327	-	expression tag
Gly 328	-	expression tag
Lys 329	-	expression tag
Leu 330	-	expression tag
Gly 331	-	expression tag
Leu 332	-	expression tag
Ile 333	-	expression tag
Thr 334	-	expression tag
Asn 335	-	expression tag
Thr 336	-	expression tag
Ile 337	-	expression tag
Ala 338	-	expression tag
Gly 339	-	expression tag
Val 340	-	expression tag
Ala 341	-	expression tag
Gly 342	-	expression tag
Leu 343	-	expression tag
Ile 344	-	expression tag
Thr 345	-	expression tag
Gly 346	-	expression tag
Gly 347	-	expression tag
Arg 348	-	expression tag
Arg 349	-	expression tag
Thr 350	-	expression tag
Arg 351	-	expression tag
Arg 352	-	expression tag

D, E, F: 504 - 629 (UniProt: P87666)

PDB	External Database	Details
Glu 502	-	expression tag
Val 503	-	expression tag
Phe 517	Tyr 517	conflict
Val 630	-	expression tag
Glu 631	-	expression tag
Val 632	-	expression tag
Asp 633	-	expression tag
Asp 634	-	expression tag
Asp 635	-	expression tag
Asp 636	-	expression tag
Lys 637	-	expression tag
Ala 638	-	expression tag
Gly 639	-	expression tag
Trp 640	-	expression tag
Ser 641	-	expression tag
His 642	-	expression tag
Pro 643	-	expression tag
Gln 644	-	expression tag
Phe 645	-	expression tag
Glu 646	-	expression tag
Lys 647	-	expression tag
Gly 648	-	expression tag
Gly 649	-	expression tag
Gly 650	-	expression tag
Ser 651	-	expression tag
Gly 652	-	expression tag
Gly 653	-	expression tag
Gly 654	-	expression tag
Ser 655	-	expression tag
Gly 656	-	expression tag
Gly 657	-	expression tag
Gly 658	-	expression tag
Ser 659	-	expression tag
Trp 660	-	expression tag
Ser 661	-	expression tag
His 662	-	expression tag
Pro 663	-	expression tag
Gln 664	-	expression tag
Phe 665	-	expression tag
Glu 666	-	expression tag
Lys 667	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	12
	Total formula weight	235072.0
Branched	Number of molecules	6
	Total formula weight	4492.1
Non-Polymers*	Number of molecules	6
	Total formula weight	1327.2
All*	Total formula weight	240891.3

*Water molecules are not included.