6DYY
Crystal structure of Helicobacter pylori 5'-methylthioadenosine/S-adenosyl homocysteine nucleosidase (MTAN) complexed with (3R,4S)-1-((4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl)-4-(((3-(1-butyl-1H-1,2,3-triazol-4-yl)propyl)thio)methyl)pyrrolidin-3-ol
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D | 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase | polymer | 245 | 26886.9 | 4 | UniProt (A0A1W0VQJ9) Pfam (PF01048) UniProt (by SIFTS) (Q9ZMY2) In PDB | Helicobacter pylori (Campylobacter pylori) | |
2 | A, B, C, D | 1,2-ETHANEDIOL | non-polymer | 62.1 | 7 | Chemie (EDO) | |||
3 | A, B | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
4 | A, B, C, D | (3R,4S)-1-[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-({[3-(1-butyl-1H-1,2,3-triazol-4-yl)propyl]sulfanyl}methyl)pyrrolidin-3-ol | non-polymer | 444.6 | 4 | Chemie (OS6) | |||
5 | water | water | 18.0 | 889 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1 - 230 (UniProt: A0A1W0VQJ9)
PDB | External Database | Details |
---|---|---|
Met -14 | - | expression tag |
Gly -13 | - | expression tag |
His -12 | - | expression tag |
His -11 | - | expression tag |
His -10 | - | expression tag |
His -9 | - | expression tag |
His -8 | - | expression tag |
His -7 | - | expression tag |
Glu -6 | - | expression tag |
Asn -5 | - | expression tag |
Leu -4 | - | expression tag |
Tyr -3 | - | expression tag |
Phe -2 | - | expression tag |
Gln -1 | - | expression tag |
Gly 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 107547.5 | |
Non-Polymers* | Number of molecules | 13 |
Total formula weight | 2261.5 | |
All* | Total formula weight | 109809.0 |