6DYY

Crystal structure of Helicobacter pylori 5'-methylthioadenosine/S-adenosyl homocysteine nucleosidase (MTAN) complexed with (3R,4S)-1-((4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl)-4-(((3-(1-butyl-1H-1,2,3-triazol-4-yl)propyl)thio)methyl)pyrrolidin-3-ol

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0005829	cellular_component	cytosol
A	0008652	biological_process	amino acid biosynthetic process
A	0008782	molecular_function	adenosylhomocysteine nucleosidase activity
A	0008930	molecular_function	methylthioadenosine nucleosidase activity
A	0009086	biological_process	methionine biosynthetic process
A	0009116	biological_process	nucleoside metabolic process
A	0009164	biological_process	nucleoside catabolic process
A	0009234	biological_process	menaquinone biosynthetic process
A	0016787	molecular_function	hydrolase activity
A	0019284	biological_process	L-methionine salvage from S-adenosylmethionine
A	0019509	biological_process	L-methionine salvage from methylthioadenosine
A	0102246	molecular_function	6-amino-6-deoxyfutalosine hydrolase activity
B	0003824	molecular_function	catalytic activity
B	0005829	cellular_component	cytosol
B	0008652	biological_process	amino acid biosynthetic process
B	0008782	molecular_function	adenosylhomocysteine nucleosidase activity
B	0008930	molecular_function	methylthioadenosine nucleosidase activity
B	0009086	biological_process	methionine biosynthetic process
B	0009116	biological_process	nucleoside metabolic process
B	0009164	biological_process	nucleoside catabolic process
B	0009234	biological_process	menaquinone biosynthetic process
B	0016787	molecular_function	hydrolase activity
B	0019284	biological_process	L-methionine salvage from S-adenosylmethionine
B	0019509	biological_process	L-methionine salvage from methylthioadenosine
B	0102246	molecular_function	6-amino-6-deoxyfutalosine hydrolase activity
C	0003824	molecular_function	catalytic activity
C	0005829	cellular_component	cytosol
C	0008652	biological_process	amino acid biosynthetic process
C	0008782	molecular_function	adenosylhomocysteine nucleosidase activity
C	0008930	molecular_function	methylthioadenosine nucleosidase activity
C	0009086	biological_process	methionine biosynthetic process
C	0009116	biological_process	nucleoside metabolic process
C	0009164	biological_process	nucleoside catabolic process
C	0009234	biological_process	menaquinone biosynthetic process
C	0016787	molecular_function	hydrolase activity
C	0019284	biological_process	L-methionine salvage from S-adenosylmethionine
C	0019509	biological_process	L-methionine salvage from methylthioadenosine
C	0102246	molecular_function	6-amino-6-deoxyfutalosine hydrolase activity
D	0003824	molecular_function	catalytic activity
D	0005829	cellular_component	cytosol
D	0008652	biological_process	amino acid biosynthetic process
D	0008782	molecular_function	adenosylhomocysteine nucleosidase activity
D	0008930	molecular_function	methylthioadenosine nucleosidase activity
D	0009086	biological_process	methionine biosynthetic process
D	0009116	biological_process	nucleoside metabolic process
D	0009164	biological_process	nucleoside catabolic process
D	0009234	biological_process	menaquinone biosynthetic process
D	0016787	molecular_function	hydrolase activity
D	0019284	biological_process	L-methionine salvage from S-adenosylmethionine
D	0019509	biological_process	L-methionine salvage from methylthioadenosine
D	0102246	molecular_function	6-amino-6-deoxyfutalosine hydrolase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue EDO A 301

Chain	Residue
A	THR123
A	GLY125
A	SER126
A	HOH464
C	ASP209
D	PHE107

---

site_id	AC2
Number of Residues	7
Details	binding site for residue MG A 302

Chain	Residue
A	HOH418
A	HOH428
A	HOH579
A	HOH591
A	GLU229
A	HOH401
A	HOH403

---

site_id	AC3
Number of Residues	19
Details	binding site for residue OS6 A 303

Chain	Residue
A	ILE52
A	VAL78
A	ALA79
A	GLY80
A	GLN152
A	PHE153
A	VAL154
A	VAL172
A	GLU173
A	MET174
A	GLU175
A	SER197
A	ASP198
A	ALA200
A	PHE208
A	HOH416
B	HIS109
B	PRO115
B	GLU116

---

site_id	AC4
Number of Residues	7
Details	binding site for residue EDO B 301

Chain	Residue
B	THR123
B	GLY125
B	SER126
B	HOH403
B	HOH562
C	PHE107
D	ASP209

---

site_id	AC5
Number of Residues	7
Details	binding site for residue EDO B 302

Chain	Residue
A	ALA106
A	PHE107
B	GLY205
B	MET206
B	ASP209
B	HOH457
B	HOH492

---

site_id	AC6
Number of Residues	6
Details	binding site for residue EDO B 303

Chain	Residue
B	GLN138
B	HIS139
B	SER165
B	GLU166
B	HOH536
B	HOH546

---

site_id	AC7
Number of Residues	7
Details	binding site for residue MG B 304

Chain	Residue
B	LYS133
B	HOH401
B	HOH411
B	HOH424
B	HOH453
B	HOH585
B	HOH601

---

site_id	AC8
Number of Residues	21
Details	binding site for residue OS6 B 305

Chain	Residue
A	LEU104
A	HIS109
A	PRO115
B	ALA9
B	ILE52
B	VAL78
B	ALA79
B	GLY80
B	GLN152
B	PHE153
B	VAL154
B	VAL172
B	GLU173
B	MET174
B	GLU175
B	SER197
B	ASP198
B	PHE208
B	HOH423
C	LYS132
C	HOH483

---

site_id	AC9
Number of Residues	5
Details	binding site for residue EDO C 301

Chain	Residue
C	GLY32
C	ASN33
C	VAL34
C	TYR49
C	HOH478

---

site_id	AD1
Number of Residues	6
Details	binding site for residue EDO C 302

Chain	Residue
A	LYS157
C	SER156
C	LYS157
C	ASP201
C	GLU202
C	HOH413

---

site_id	AD2
Number of Residues	19
Details	binding site for residue OS6 C 303

Chain	Residue
C	VAL154
C	VAL172
C	GLU173
C	MET174
C	GLU175
C	SER197
C	ASP198
C	PHE208
C	HOH417
D	PHE107
D	HIS109
A	GLU122
C	ALA9
C	ILE52
C	VAL78
C	ALA79
C	GLY80
C	GLN152
C	PHE153

---

site_id	AD3
Number of Residues	5
Details	binding site for residue EDO D 301

Chain	Residue
D	GLY32
D	ASN33
D	VAL34
D	TYR49
D	HOH446

---

site_id	AD4
Number of Residues	16
Details	binding site for residue OS6 D 302

Chain	Residue
C	HIS109
D	ALA9
D	ILE52
D	VAL78
D	ALA79
D	GLY80
D	PHE153
D	VAL154
D	VAL172
D	GLU173
D	MET174
D	GLU175
D	SER197
D	ASP198
D	PHE208
D	HOH410

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"20954236","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	Active site: {"description":"Proton donor","evidences":[{"source":"PubMed","id":"20954236","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	8
Details	Binding site: {}

Chain

Residue

Details

---