6DQC
LINKED KDM5A JMJ DOMAIN BOUND TO THE INHIBITOR N50 i.e. 2-(4-((2-(dimethylamino)ethyl)(ethyl)carbamoyl)-5-(4-methoxyphenyl)-1H-pyrazol-1-yl)isonicotinic acid
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Linked KDM5A Jmj Domain | polymer | 330 | 37944.8 | 1 | UniProt (P29375) Pfam (PF02375) Pfam (PF02373) In PDB | Homo sapiens (Human) | Histone demethylase JARID1A,Jumonji/ARID domain-containing protein 1A,Retinoblastoma-binding protein 2,RBBP-2,Histone demethylase JARID1A,Jumonji/ARID domain-containing protein 1A,Retinoblastoma-binding protein 2,RBBP-2 |
2 | A | 2-[4-{[2-(dimethylamino)ethyl](ethyl)carbamoyl}-5-(4-methoxyphenyl)-1H-pyrazol-1-yl]pyridine-4-carboxylic acid | non-polymer | 437.5 | 1 | Chemie (H5Y) | |||
3 | A | MANGANESE (II) ION | non-polymer | 54.9 | 1 | Chemie (MN) | |||
4 | A | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 1 | Chemie (DMS) | |||
5 | A | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
6 | A | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
7 | water | water | 18.0 | 162 | Chemie (HOH) |
Sequence modifications
A: 1 - 87 (UniProt: P29375)
A: 348 - 588 (UniProt: P29375)
PDB | External Database | Details |
---|---|---|
His -1 | - | expression tag |
Asn 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 37944.8 | |
Non-Polymers* | Number of molecules | 5 |
Total formula weight | 758.7 | |
All* | Total formula weight | 38703.6 |