6DQC
LINKED KDM5A JMJ DOMAIN BOUND TO THE INHIBITOR N50 i.e. 2-(4-((2-(dimethylamino)ethyl)(ethyl)carbamoyl)-5-(4-methoxyphenyl)-1H-pyrazol-1-yl)isonicotinic acid
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 18 |
Details | binding site for residue H5Y A 601 |
Chain | Residue |
A | ARG73 |
A | ASP486 |
A | LYS501 |
A | TRP503 |
A | HIS571 |
A | MN602 |
A | DMS603 |
A | HOH750 |
A | HOH806 |
A | HOH812 |
A | GLN75 |
A | TYR409 |
A | ALA411 |
A | TYR472 |
A | SER479 |
A | PHE480 |
A | HIS483 |
A | GLU485 |
site_id | AC2 |
Number of Residues | 5 |
Details | binding site for residue MN A 602 |
Chain | Residue |
A | HIS483 |
A | GLU485 |
A | HIS571 |
A | H5Y601 |
A | HOH750 |
site_id | AC3 |
Number of Residues | 5 |
Details | binding site for residue DMS A 603 |
Chain | Residue |
A | TYR472 |
A | ALA583 |
A | ASN585 |
A | H5Y601 |
A | HOH748 |
site_id | AC4 |
Number of Residues | 4 |
Details | binding site for residue GOL A 604 |
Chain | Residue |
A | ASN556 |
A | HOH702 |
A | HOH776 |
A | HOH818 |
site_id | AC5 |
Number of Residues | 4 |
Details | binding site for residue SO4 A 605 |
Chain | Residue |
A | GLU64 |
A | VAL65 |
A | LYS66 |
A | ARG429 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 50 |
Details | ZN_FING: PHD-type 1 => ECO:0000255|PROSITE-ProRule:PRU00146 |
Chain | Residue | Details |
site_id | SWS_FT_FI2 |
Number of Residues | 4 |
Details | BINDING: BINDING => ECO:0000269|PubMed:26645689, ECO:0000269|PubMed:27427228 |
Chain | Residue | Details |
A | TYR409 | |
A | SER491 | |
A | ASN493 | |
A | LYS501 |
site_id | SWS_FT_FI3 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00538, ECO:0000305|PubMed:26645689, ECO:0000305|PubMed:27214401, ECO:0000305|PubMed:27427228, ECO:0000305|PubMed:27499454 |
Chain | Residue | Details |
A | HIS483 | |
A | HIS571 |
site_id | SWS_FT_FI4 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000305|PubMed:26645689, ECO:0000305|PubMed:27214401, ECO:0000305|PubMed:27427228, ECO:0000305|PubMed:27499454 |
Chain | Residue | Details |
A | GLU485 |
site_id | SWS_FT_FI5 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
Chain | Residue | Details |
A | SER464 |
site_id | SWS_FT_FI6 |
Number of Residues | 2 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 |
Chain | Residue | Details |
A | LEU451 |