6DMH
A multiconformer ligand model of acylenzyme intermediate of meropenem bound to an SFC-1 E166A mutant
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Beta-lactamase | polymer | 270 | 29417.2 | 1 | UniProt (Q6JP75) Pfam (PF00144) Pfam (PF13354) | Serratia fonticola | |
| 2 | B, C, D, E (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 4 | Chemie (EDO) | |||
| 3 | F (A) | (4R,5S)-3-{[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl}-5-[(2S,3R)-3-hydroxy-1-oxobutan-2-yl]-4-methyl-4,5-d ihydro-1H-pyrrole-2-carboxylic acid | non-polymer | 385.5 | 1 | Chemie (MER) | |||
| 4 | G (A) | water | water | 18.0 | 437 | Chemie (HOH) |
Sequence modifications
A: 22 - 292 (UniProt: Q6JP75)
| PDB | External Database | Details |
|---|---|---|
| Ala 166 | Glu 171 | engineered mutation |
| Ala 255 | Gly 259 | conflict |
| Arg 270 | Lys 274 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 29417.2 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 633.8 | |
| All* | Total formula weight | 30050.9 |
