6DM8
Understanding the Species Selectivity of Myeloid cell leukemia-1 (Mcl-1) inhibitors
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... | Induced myeloid leukemia cell differentiation protein Mcl-1 homolog - MBP chimera | polymer | 518 | 57441.1 | 8 | UniProt (P0AEX9) UniProt (P97287) Pfam (PF01547) Pfam (PF00452) In PDB | Escherichia coli (strain K12) | MBP,MMBP,Maltodextrin-binding protein,Bcl-2-related protein EAT/mcl1 |
| 2 | I, J, K, L, M... | alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose | branched | 342.3 | 8 | In PDB BIRD (PRD_900001) GlyTouCan (G07411ON) | alpha-maltose | ||
| 3 | D, E, F, G, H... | 4-{8-chloro-11-[3-(4-chloro-3,5-dimethylphenoxy)propyl]-1-oxo-7-(1,3,5-trimethyl-1H-pyrazol-4-yl)-4,5-dihydro-1H-[1,4]diazepino[1,2-a]indol-2(3H)-yl}-1-methyl-1H-indole-6-carboxylic acid | non-polymer | 712.7 | 24 | Chemie (6AK) | |||
| 4 | water | water | 18.0 | 473 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E, F, G, H: -214 - 151 (UniProt: P0AEX9)
A, B, C, D, E, F, G, H: 154 - 302 (UniProt: P97287)
| PDB | External Database | Details |
|---|---|---|
| Gly -215 | - | expression tag |
| Gly 152 | - | linker |
| Ser 153 | - | linker |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 459528.5 | |
| Branched | Number of molecules | 8 |
| Total formula weight | 2738.4 | |
| Non-Polymers* | Number of molecules | 24 |
| Total formula weight | 17103.9 | |
| All* | Total formula weight | 479370.8 |
