6DM8

Understanding the Species Selectivity of Myeloid cell leukemia-1 (Mcl-1) inhibitors

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
A	0006974	biological_process	DNA damage response
A	0008643	biological_process	carbohydrate transport
A	0015144	molecular_function	carbohydrate transmembrane transporter activity
A	0015768	biological_process	maltose transport
A	0016020	cellular_component	membrane
A	0030288	cellular_component	outer membrane-bounded periplasmic space
A	0034219	biological_process	carbohydrate transmembrane transport
A	0034289	biological_process	detection of maltose stimulus
A	0042597	cellular_component	periplasmic space
A	0042956	biological_process	maltodextrin transmembrane transport
A	0042981	biological_process	regulation of apoptotic process
A	0043190	cellular_component	ATP-binding cassette (ABC) transporter complex
A	0055052	cellular_component	ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
A	0055085	biological_process	transmembrane transport
A	0060326	biological_process	cell chemotaxis
A	1901982	molecular_function	maltose binding
A	1990060	cellular_component	maltose transport complex
B	0005515	molecular_function	protein binding
B	0006974	biological_process	DNA damage response
B	0008643	biological_process	carbohydrate transport
B	0015144	molecular_function	carbohydrate transmembrane transporter activity
B	0015768	biological_process	maltose transport
B	0016020	cellular_component	membrane
B	0030288	cellular_component	outer membrane-bounded periplasmic space
B	0034219	biological_process	carbohydrate transmembrane transport
B	0034289	biological_process	detection of maltose stimulus
B	0042597	cellular_component	periplasmic space
B	0042956	biological_process	maltodextrin transmembrane transport
B	0042981	biological_process	regulation of apoptotic process
B	0043190	cellular_component	ATP-binding cassette (ABC) transporter complex
B	0055052	cellular_component	ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
B	0055085	biological_process	transmembrane transport
B	0060326	biological_process	cell chemotaxis
B	1901982	molecular_function	maltose binding
B	1990060	cellular_component	maltose transport complex
C	0005515	molecular_function	protein binding
C	0006974	biological_process	DNA damage response
C	0008643	biological_process	carbohydrate transport
C	0015144	molecular_function	carbohydrate transmembrane transporter activity
C	0015768	biological_process	maltose transport
C	0016020	cellular_component	membrane
C	0030288	cellular_component	outer membrane-bounded periplasmic space
C	0034219	biological_process	carbohydrate transmembrane transport
C	0034289	biological_process	detection of maltose stimulus
C	0042597	cellular_component	periplasmic space
C	0042956	biological_process	maltodextrin transmembrane transport
C	0042981	biological_process	regulation of apoptotic process
C	0043190	cellular_component	ATP-binding cassette (ABC) transporter complex
C	0055052	cellular_component	ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
C	0055085	biological_process	transmembrane transport
C	0060326	biological_process	cell chemotaxis
C	1901982	molecular_function	maltose binding
C	1990060	cellular_component	maltose transport complex
D	0005515	molecular_function	protein binding
D	0006974	biological_process	DNA damage response
D	0008643	biological_process	carbohydrate transport
D	0015144	molecular_function	carbohydrate transmembrane transporter activity
D	0015768	biological_process	maltose transport
D	0016020	cellular_component	membrane
D	0030288	cellular_component	outer membrane-bounded periplasmic space
D	0034219	biological_process	carbohydrate transmembrane transport
D	0034289	biological_process	detection of maltose stimulus
D	0042597	cellular_component	periplasmic space
D	0042956	biological_process	maltodextrin transmembrane transport
D	0042981	biological_process	regulation of apoptotic process
D	0043190	cellular_component	ATP-binding cassette (ABC) transporter complex
D	0055052	cellular_component	ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
D	0055085	biological_process	transmembrane transport
D	0060326	biological_process	cell chemotaxis
D	1901982	molecular_function	maltose binding
D	1990060	cellular_component	maltose transport complex
E	0005515	molecular_function	protein binding
E	0006974	biological_process	DNA damage response
E	0008643	biological_process	carbohydrate transport
E	0015144	molecular_function	carbohydrate transmembrane transporter activity
E	0015768	biological_process	maltose transport
E	0016020	cellular_component	membrane
E	0030288	cellular_component	outer membrane-bounded periplasmic space
E	0034219	biological_process	carbohydrate transmembrane transport
E	0034289	biological_process	detection of maltose stimulus
E	0042597	cellular_component	periplasmic space
E	0042956	biological_process	maltodextrin transmembrane transport
E	0042981	biological_process	regulation of apoptotic process
E	0043190	cellular_component	ATP-binding cassette (ABC) transporter complex
E	0055052	cellular_component	ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
E	0055085	biological_process	transmembrane transport
E	0060326	biological_process	cell chemotaxis
E	1901982	molecular_function	maltose binding
E	1990060	cellular_component	maltose transport complex
F	0005515	molecular_function	protein binding
F	0006974	biological_process	DNA damage response
F	0008643	biological_process	carbohydrate transport
F	0015144	molecular_function	carbohydrate transmembrane transporter activity
F	0015768	biological_process	maltose transport
F	0016020	cellular_component	membrane
F	0030288	cellular_component	outer membrane-bounded periplasmic space
F	0034219	biological_process	carbohydrate transmembrane transport
F	0034289	biological_process	detection of maltose stimulus
F	0042597	cellular_component	periplasmic space
F	0042956	biological_process	maltodextrin transmembrane transport
F	0042981	biological_process	regulation of apoptotic process
F	0043190	cellular_component	ATP-binding cassette (ABC) transporter complex
F	0055052	cellular_component	ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
F	0055085	biological_process	transmembrane transport
F	0060326	biological_process	cell chemotaxis
F	1901982	molecular_function	maltose binding
F	1990060	cellular_component	maltose transport complex
G	0005515	molecular_function	protein binding
G	0006974	biological_process	DNA damage response
G	0008643	biological_process	carbohydrate transport
G	0015144	molecular_function	carbohydrate transmembrane transporter activity
G	0015768	biological_process	maltose transport
G	0016020	cellular_component	membrane
G	0030288	cellular_component	outer membrane-bounded periplasmic space
G	0034219	biological_process	carbohydrate transmembrane transport
G	0034289	biological_process	detection of maltose stimulus
G	0042597	cellular_component	periplasmic space
G	0042956	biological_process	maltodextrin transmembrane transport
G	0042981	biological_process	regulation of apoptotic process
G	0043190	cellular_component	ATP-binding cassette (ABC) transporter complex
G	0055052	cellular_component	ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
G	0055085	biological_process	transmembrane transport
G	0060326	biological_process	cell chemotaxis
G	1901982	molecular_function	maltose binding
G	1990060	cellular_component	maltose transport complex
H	0005515	molecular_function	protein binding
H	0006974	biological_process	DNA damage response
H	0008643	biological_process	carbohydrate transport
H	0015144	molecular_function	carbohydrate transmembrane transporter activity
H	0015768	biological_process	maltose transport
H	0016020	cellular_component	membrane
H	0030288	cellular_component	outer membrane-bounded periplasmic space
H	0034219	biological_process	carbohydrate transmembrane transport
H	0034289	biological_process	detection of maltose stimulus
H	0042597	cellular_component	periplasmic space
H	0042956	biological_process	maltodextrin transmembrane transport
H	0042981	biological_process	regulation of apoptotic process
H	0043190	cellular_component	ATP-binding cassette (ABC) transporter complex
H	0055052	cellular_component	ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
H	0055085	biological_process	transmembrane transport
H	0060326	biological_process	cell chemotaxis
H	1901982	molecular_function	maltose binding
H	1990060	cellular_component	maltose transport complex

Functional Information from PROSITE/UniProt

site_id	PS01037
Number of Residues	18
Details	SBP_BACTERIAL_1 Bacterial extracellular solute-binding proteins, family 1 signature. PIAvEalSLIYNkdlLpN

Chain	Residue	Details
A	PRO-108-ASN-91

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site_id	PS01080
Number of Residues	20
Details	BH1 Apoptosis regulator, Bcl-2 family BH1 motif signature. VFkDGvtNWGRIVTLIsFGA

Chain	Residue	Details
A	VAL234-ALA253

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site_id	PS01258
Number of Residues	12
Details	BH2 Apoptosis regulator, Bcl-2 family BH2 motif signature. WLvkqRGWDgFV

Chain	Residue	Details
A	TRP286-VAL297

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site_id	PS01259
Number of Residues	15
Details	BH3 Apoptosis regulator, Bcl-2 family BH3 motif signature. AletLRrVGDGVQRN

Chain	Residue	Details
A	ALA190-ASN204

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	24
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:Q07820

Chain	Residue	Details
A	LYS175
D	LYS175
D	LYS178
E	LYS175
E	LYS178
F	LYS175
F	LYS178
G	LYS175
G	LYS178
H	LYS175
H	LYS178
A	LYS178
B	LYS175
B	LYS178
C	LYS175
C	LYS178

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