6DM0

Open state GluA2 in complex with STZ and blocked by IEM-1460, after micelle signal subtraction

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D	Glutamate receptor 2,Voltage-dependent calcium channel gamma-2 subunit	polymer	1031	115178.5	4	UniProt (P19491) UniProt (Q9Y698) Pfam (PF01094) Pfam (PF10613) Pfam (PF00060) Pfam (PF00822) In PDB	Rattus norvegicus (Rat)	GluR-2,AMPA-selective glutamate receptor 2,GluR-B,GluR-K2,Glutamate receptor ionotropic,AMPA 2,GluA2,Neuronal voltage-gated calcium channel gamma-2 subunit,Transmembrane AMPAR regulatory protein gamma-2,TARP gamma-2
2	A, B, C, D	GLUTAMIC ACID	non-polymer		147.1	4	Chemie (GLU)
3	A, B, C, D	CYCLOTHIAZIDE	non-polymer		389.9	4	Chemie (CYZ)
4	B	N,N,N-trimethyl-5-({[(3s,5s,7s)-tricyclo[3.3.1.1~3,7~]decan-1-yl]methyl}amino)pentan-1-aminium	non-polymer		293.5	1	Chemie (GZD)

Sequence modifications

A, B, C, D: 10 - 998 (UniProt: P19491)

PDB	External Database	Details
Glu 241	Asn 256	conflict
Leu 382	Val 397	conflict
-	Leu 399	deletion
-	Thr 400	deletion
-	Glu 401	deletion
-	Leu 402	deletion
-	Pro 403	deletion
-	Ser 404	deletion
Glu 384	Gly 405	conflict
Asp 385	Asn 406	conflict
Gln 392	Asn 413	conflict
Gly 999	-	linker
Thr 1000	-	linker

A, B, C, D: 1001 - 1207 (UniProt: Q9Y698)

PDB	External Database	Details
Asp 1047	Asn 48	conflict
Thr 1208	-	expression tag
Gly 1209	-	expression tag
Gly 1210	-	expression tag
Ala 1211	-	expression tag
Glu 1212	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	460714.1
Non-Polymers*	Number of molecules	9
	Total formula weight	2441.5
All*	Total formula weight	463155.7

*Water molecules are not included.