6DCU

Crystal structure of PPAR gamma co-crystallized with nTZDpa

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Peroxisome proliferator-activated receptor gamma	polymer	301	34619.0	2	UniProt (P37231) Pfam (PF00104) In PDB	Homo sapiens (Human)	PPAR-gamma,Nuclear receptor subfamily 1 group C member 3
2	A, B	5-CHLORO-1-(4-CHLOROBENZYL)-3-(PHENYLTHIO)-1H-INDOLE-2-CARBOXYLIC ACID	non-polymer		428.3	2	Chemie (NZA)

Sequence modifications

A, B: 203 - 477 (UniProt: P37231)

PDB	External Database	Details
Met 181	-	initiating methionine
Ala 182	-	expression tag
His 183	-	expression tag
His 184	-	expression tag
His 185	-	expression tag
His 186	-	expression tag
His 187	-	expression tag
His 188	-	expression tag
Val 189	-	expression tag
Asp 190	-	expression tag
Asp 191	-	expression tag
Asp 192	-	expression tag
Asp 193	-	expression tag
Lys 194	-	expression tag
Met 195	-	expression tag
Glu 196	-	expression tag
Asn 197	-	expression tag
Leu 198	-	expression tag
Tyr 199	-	expression tag
Phe 200	-	expression tag
Gln 201	-	expression tag
Gly 202	-	expression tag
Leu 478	-	expression tag
Val 479	-	expression tag
Pro 480	-	expression tag
Arg 481	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	69238.0
Non-Polymers*	Number of molecules	2
	Total formula weight	856.7
All*	Total formula weight	70094.7

*Water molecules are not included.