6DCC

Structure of methylphosphate capping enzyme methyltransferase domain in complex with 5' end of 7SK RNA

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	7SK snRNA methylphosphate capping enzyme	polymer	309	35122.8	1	UniProt (Q7L2J0) Pfam (PF06859)	Homo sapiens (Human)	MePCE,Bicoid-interacting protein 3 homolog,Bin3 homolog
2	B (B)	human 7SK RNA stem-loop 1 proximal methylated	polymer	36	11723.9	1		Homo sapiens
3	C (A)	S-ADENOSYL-L-HOMOCYSTEINE	non-polymer		384.4	1	Chemie (SAH)
4	D (A)	SULFATE ION	non-polymer		96.1	1	Chemie (SO4)
5	E, F (A, B)	water	water		18.0	91	Chemie (HOH)

Sequence modifications

A: 400 - 689 (UniProt: Q7L2J0)

PDB	External Database	Details
Met 381	-	expression tag
Gly 382	-	expression tag
Ser 383	-	expression tag
Ser 384	-	expression tag
His 385	-	expression tag
His 386	-	expression tag
His 387	-	expression tag
His 388	-	expression tag
His 389	-	expression tag
His 390	-	expression tag
Ser 391	-	expression tag
Ser 392	-	expression tag
Gly 393	-	expression tag
Leu 394	-	expression tag
Val 395	-	expression tag
Pro 396	-	expression tag
Arg 397	-	expression tag
Gly 398	-	expression tag
Ser 399	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	46846.6
Non-Polymers*	Number of molecules	2
	Total formula weight	480.5
All*	Total formula weight	47327.1

*Water molecules are not included.