6DC5

RSV prefusion F in complex with AM22 Fab

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, D, G	RSV fusion glycoprotein	polymer	568	63218.3	3	UniProt (P03420) UniProt (M1E1E4) Pfam (PF00523) Pfam (PF07921) In PDB	Human respiratory syncytial virus A (strain A2)	Protein F
2	B, E, H	Fab AM22 heavy chain	polymer	228	24123.2	3	UniProt (Q6GMX6) Pfam (PF07686) Pfam (PF07654) In PDB	Homo sapiens (Human)
3	C, F, I	Fab AM22 light chain	polymer	215	23273.9	3	UniProt (Q8TCD0) Pfam (PF07686) Pfam (PF07654) In PDB	Homo sapiens (Human)
4	A, D, G	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	3	Chemie (NAG)
5	A, D, G	CADMIUM ION	non-polymer		112.4	3	Chemie (CD)
6	C, F, I	DI(HYDROXYETHYL)ETHER	non-polymer		106.1	6	Chemie (PEG)

Sequence modifications

A, D, G: 1 - 513 (UniProt: P03420)

PDB	External Database	Details
Ala 102	Pro 102	variant
Cys 155	Ser 155	engineered mutation
Phe 190	Ser 190	engineered mutation
Leu 207	Val 207	engineered mutation
Cys 290	Ser 290	engineered mutation
Val 379	Ile 379	variant
Val 447	Met 447	variant
Ser 514	-	linker
Ala 515	-	linker
Ile 516	-	linker
Gly 517	-	linker

A, D, G: 518 - 545 (UniProt: M1E1E4)
A, D, G: 546 - 568 (PDB: 6DC5)
B, E, H: 1 - 100 (PDB: 6DC5)
B, E, H: 101 - 217 (UniProt: Q6GMX6)
C, F, I: 1 - 106 (PDB: 6DC5)
C, F, I: 107 - 214 (UniProt: Q8TCD0)

Contents of the asymmetric unit

Polymers	Number of chains	9
	Total formula weight	331846.5
Non-Polymers*	Number of molecules	12
	Total formula weight	1637.6
All*	Total formula weight	333484.1

*Water molecules are not included.