6DC3

RSV prefusion F bound to RSD5 Fab

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	H	Fab RSD5-Germline Heavy Chain	polymer	230	24454.4	1	UniProt (Q6N089) Pfam (PF07686) Pfam (PF07654) In PDB	Homo sapiens (Human)
2	L	Fab RSD5-Germline Light Chain	polymer	216	22819.2	1	UniProt (Q8N355) Pfam (PF07686) Pfam (PF07654) In PDB	Homo sapiens (Human)
3	F	RSV fusion glycoprotein	polymer	568	63218.3	1	UniProt (P03420) UniProt (M1E1E4) Pfam (PF00523) Pfam (PF07921) In PDB	Human respiratory syncytial virus A (strain A2)	Protein F
4	H, L, F	SULFATE ION	non-polymer		96.1	13	Chemie (SO4)
5	F	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	2	Chemie (NAG)

Sequence modifications

H: 1 - 102 (PDB: 6DC3)
H: 103 - 216 (UniProt: Q6N089)
L: 1 - 95 (PDB: 6DC3)
L: 96 - 213 (UniProt: Q8N355)
F: 1 - 513 (UniProt: P03420)

PDB	External Database	Details
Ala 102	Pro 102	variant
Cys 155	Ser 155	engineered mutation
Phe 190	Ser 190	engineered mutation
Leu 207	Val 207	engineered mutation
Cys 290	Ser 290	engineered mutation
Val 379	Ile 379	variant
Val 447	Met 447	variant
Ser 514	-	linker
Ala 515	-	linker
Ile 516	-	linker
Gly 517	-	linker

F: 518 - 545 (UniProt: M1E1E4)
F: 546 - 568 (PDB: 6DC3)

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	110491.9
Non-Polymers*	Number of molecules	15
	Total formula weight	1691.2
All*	Total formula weight	112183.1

*Water molecules are not included.