6D5E

Ras:SOS:Ras in complex with a small molecule activator

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	GTPase HRas	polymer	167	18856.1	1	UniProt (P01112) Pfam (PF00071) In PDB	Homo sapiens (Human)	H-Ras-1,Ha-Ras,Transforming protein p21,c-H-ras,p21ras
2	B	Son of sevenless homolog 1	polymer	482	56589.8	1	UniProt (Q07889) Pfam (PF00618) Pfam (PF00617) In PDB	Homo sapiens (Human)	SOS-1
3	C	GTPase HRas	polymer	167	18932.2	1	UniProt (P01112) Pfam (PF00071) In PDB	Homo sapiens (Human)	H-Ras-1,Ha-Ras,Transforming protein p21,c-H-ras,p21ras
4	A	PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER	non-polymer		522.2	1	Chemie (GNP)
5	A	MAGNESIUM ION	non-polymer		24.3	1	Chemie (MG)
6	A, B, C	CHLORIDE ION	non-polymer		35.5	4	Chemie (CL)
7	B	1-[(2S)-1-{6-chloro-1-[(4-fluoro-3,5-dimethylphenyl)methyl]-2-(piperazin-1-yl)-1H-benzimidazol-4-yl}pyrrolidin-2-yl]methanamine	non-polymer		471.0	1	Chemie (FVG)
8	B	FORMIC ACID	non-polymer		46.0	6	Chemie (FMT)
9	B	GLYCEROL	non-polymer		92.1	3	Chemie (GOL)
10	C	SODIUM ION	non-polymer		23.0	1	Chemie (NA)
11		water	water		18.0	1050	Chemie (HOH)

Sequence modifications

A: 1 - 166 (UniProt: P01112)

PDB	External Database	Details
Gly 0	-	expression tag
Ala 64	Tyr 64	conflict

B: 566 - 1046 (UniProt: Q07889)

PDB	External Database	Details
Gly 565	-	expression tag

C: 1 - 166 (UniProt: P01112)

PDB	External Database	Details
Gly 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	94378.2
Non-Polymers*	Number of molecules	17
	Total formula weight	1734.7
All*	Total formula weight	96112.9

*Water molecules are not included.