Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003924 | molecular_function | GTPase activity |
| A | 0005525 | molecular_function | GTP binding |
| A | 0007165 | biological_process | signal transduction |
| A | 0016020 | cellular_component | membrane |
| B | 0005085 | molecular_function | guanyl-nucleotide exchange factor activity |
| B | 0007264 | biological_process | small GTPase-mediated signal transduction |
| C | 0003924 | molecular_function | GTPase activity |
| C | 0005525 | molecular_function | GTP binding |
| C | 0007165 | biological_process | signal transduction |
| C | 0016020 | cellular_component | membrane |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 30 |
| Details | binding site for residue GNP A 201 |
| Chain | Residue |
| A | GLY12 |
| A | ASP30 |
| A | GLU31 |
| A | TYR32 |
| A | PRO34 |
| A | THR35 |
| A | GLY60 |
| A | GLN61 |
| A | ASN116 |
| A | LYS117 |
| A | ASP119 |
| A | GLY13 |
| A | LEU120 |
| A | SER145 |
| A | ALA146 |
| A | LYS147 |
| A | MG202 |
| A | HOH311 |
| A | HOH326 |
| A | HOH356 |
| A | HOH364 |
| A | HOH371 |
| A | VAL14 |
| A | HOH396 |
| A | GLY15 |
| A | LYS16 |
| A | SER17 |
| A | ALA18 |
| A | PHE28 |
| A | VAL29 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue MG A 202 |
| Chain | Residue |
| A | SER17 |
| A | THR35 |
| A | GNP201 |
| A | HOH311 |
| A | HOH371 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | binding site for residue CL A 203 |
| Chain | Residue |
| A | ARG41 |
| B | ASN976 |
| site_id | AC4 |
| Number of Residues | 14 |
| Details | binding site for residue FVG B 2001 |
| Chain | Residue |
| B | VAL852 |
| B | MET878 |
| B | ASN879 |
| B | VAL883 |
| B | TYR884 |
| B | ASP887 |
| B | PHE890 |
| B | ILE893 |
| B | LEU901 |
| B | HIS905 |
| B | GOL2009 |
| B | FMT2011 |
| B | HOH2257 |
| B | HOH2548 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue FMT B 2002 |
| Chain | Residue |
| B | MET567 |
| B | HIS616 |
| B | MET617 |
| B | HOH2161 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | binding site for residue FMT B 2003 |
| Chain | Residue |
| A | ARG128 |
| B | ARG767 |
| B | PRO768 |
| site_id | AC7 |
| Number of Residues | 7 |
| Details | binding site for residue FMT B 2004 |
| Chain | Residue |
| A | GLU37 |
| A | MET67 |
| A | GLN70 |
| B | ALA619 |
| B | ARG688 |
| B | HOH2133 |
| B | HOH2181 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | binding site for residue FMT B 2005 |
| Chain | Residue |
| B | TYR615 |
| B | HIS616 |
| B | ARG647 |
| B | TYR681 |
| B | VAL685 |
| B | HOH2226 |
| site_id | AC9 |
| Number of Residues | 1 |
| Details | binding site for residue FMT B 2006 |
| site_id | AD1 |
| Number of Residues | 5 |
| Details | binding site for residue GOL B 2007 |
| Chain | Residue |
| B | ARG786 |
| B | GLU864 |
| B | VAL1040 |
| B | HOH2113 |
| B | HOH2251 |
| site_id | AD2 |
| Number of Residues | 5 |
| Details | binding site for residue GOL B 2008 |
| Chain | Residue |
| B | SER793 |
| B | ASP794 |
| B | PRO978 |
| B | TYR979 |
| B | HOH2276 |
| site_id | AD3 |
| Number of Residues | 5 |
| Details | binding site for residue GOL B 2009 |
| Chain | Residue |
| B | PHE890 |
| B | LYS898 |
| B | FVG2001 |
| B | HOH2101 |
| B | HOH2116 |
| site_id | AD4 |
| Number of Residues | 3 |
| Details | binding site for residue CL B 2010 |
| Chain | Residue |
| B | LYS837 |
| B | PRO996 |
| B | HOH2648 |
| site_id | AD5 |
| Number of Residues | 7 |
| Details | binding site for residue FMT B 2011 |
| Chain | Residue |
| B | ASN879 |
| B | HIS905 |
| B | FVG2001 |
| B | HOH2175 |
| B | HOH2206 |
| B | HOH2329 |
| C | ARG73 |
| site_id | AD6 |
| Number of Residues | 2 |
| Details | binding site for residue CL C 201 |
| site_id | AD7 |
| Number of Residues | 6 |
| Details | binding site for residue CL C 202 |
| Chain | Residue |
| B | LYS939 |
| B | HOH2128 |
| C | ILE55 |
| C | LEU56 |
| C | ASP57 |
| C | HOH1010 |
| site_id | AD8 |
| Number of Residues | 5 |
| Details | binding site for residue NA C 203 |
| Chain | Residue |
| C | ASN85 |
| C | ASN86 |
| C | THR87 |
| C | THR124 |
| C | HOH1052 |
Functional Information from PROSITE/UniProt
| site_id | PS00720 |
| Number of Residues | 34 |
| Details | RASGEF Ras Guanine-nucleotide exchange factors domain signature. VPFfGiyLtNIlkteegnpevlkrhgkel.................INFsK |
| Chain | Residue | Details |
| B | VAL927-LYS960 | |
Functional Information from SwissProt/UniProt
| Chain | Residue | Details |
| C | GLY13 | |
| C | VAL29 | |
| C | ALA59 | |
| C | ASN116 | |
| C | SER145 | |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | MOD_RES: N-acetylmethionine; in GTPase HRas; alternate => ECO:0000269|Ref.12 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | MOD_RES: N-acetylthreonine; in GTPase HRas, N-terminally processed => ECO:0000269|Ref.12 |
| Chain | Residue | Details |
| C | CYS118 | |
| Chain | Residue | Details |
| C | THR35 | |
