6CVT
Human Aprataxin (Aptx) V263G bound to RNA-DNA, AMP and Zn product complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, D (A, B) | Aprataxin | polymer | 182 | 21217.7 | 2 | UniProt (Q7Z2E3) Pfam (PF11969) Pfam (PF16278) | Homo sapiens (Human) | Forkhead-associated domain histidine triad-like protein,FHA-HIT |
| 2 | B, E (D, G) | DNA/RNA (5'-R(P*G)-D(P*TP*TP*AP*TP*GP*AP*TP*TP*C)-3') | polymer | 10 | 3066.0 | 2 | Homo sapiens | ||
| 3 | C, F (E, H) | DNA (5'-D(*GP*AP*AP*TP*CP*AP*TP*AP*AP*C)-3') | polymer | 10 | 3037.0 | 2 | Homo sapiens | ||
| 4 | G, I (A, B) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 5 | H, J (A, B) | ADENOSINE MONOPHOSPHATE | non-polymer | 347.2 | 2 | Chemie (AMP) | |||
| 6 | K, L, M, N (A, B, G, H) | water | water | 18.0 | 11 | Chemie (HOH) |
Sequence modifications
A, B: 165 - 342 (UniProt: Q7Z2E3)
| PDB | External Database | Details |
|---|---|---|
| Gly 161 | - | expression tag |
| Ser 162 | - | expression tag |
| His 163 | - | expression tag |
| Met 164 | - | expression tag |
| Gly 263 | Val 277 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 54641.4 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 825.3 | |
| All* | Total formula weight | 55466.7 |
