6CVR
Human Aprataxin (Aptx) S242N bound to RNA-DNA, AMP and Zn product complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Aprataxin | polymer | 182 | 21286.8 | 2 | UniProt (Q7Z2E3) Pfam (PF11969) Pfam (PF16278) | Homo sapiens (Human) | Forkhead-associated domain histidine triad-like protein,FHA-HIT |
| 2 | C, E (D, G) | DNA/RNA (5'-R(P*G)-D(P*TP*TP*AP*TP*GP*AP*TP*TP*C)-3') | polymer | 10 | 3066.0 | 2 | Homo sapiens | ||
| 3 | D, F (E, H) | DNA (5'-D(*GP*AP*AP*TP*CP*AP*TP*AP*AP*C)-3') | polymer | 10 | 3037.0 | 2 | Homo sapiens | ||
| 4 | G, I (A, B) | ADENOSINE MONOPHOSPHATE | non-polymer | 347.2 | 2 | Chemie (AMP) PubChem (16397049) PubChem (16760266) PubChem (224) PubChem (40467049) PubChem (40469468) PubChem (34768) PubChem (44348067) PubChem (83862) PubChem (45358029) PubChem (46874558) PubChem (40459109) PubChem (57358045) PubChem (57879893) PubChem (57879902) PubChem (46875232) PubChem (446048) PubChem (515384) PubChem (638042) PubChem (177678969) PubChem (6083) PubChem (1549371) PubChem (5316444) PubChem (92144436) PubChem (5742864) PubChem (122197642) PubChem (12358354) PubChem (12163610) PubChem (12358355) PubChem (162290139) PubChem (162946266) PubChem (171699505) | |||
| 5 | H, J (A, B) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 6 | K, L, M, N, O... (A, B, D, E, G...) | water | water | 18.0 | 589 | Chemie (HOH) |
Sequence modifications
A, B: 165 - 342 (UniProt: Q7Z2E3)
| PDB | External Database | Details |
|---|---|---|
| Gly 161 | - | expression tag |
| Ser 162 | - | expression tag |
| His 163 | - | expression tag |
| Met 164 | - | expression tag |
| Asn 242 | Ser 256 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 54779.6 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 825.3 | |
| All* | Total formula weight | 55604.9 |
