6CVQ

Human Aprataxin (Aptx) H201Q bound to RNA-DNA, AMP and Zn product complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Aprataxin	polymer	180	21020.5	2	UniProt (Q7Z2E3) Pfam (PF11969) Pfam (PF16278)	Homo sapiens (Human)	Forkhead-associated domain histidine triad-like protein,FHA-HIT
2	C, E (D, G)	DNA/RNA (5'-R(P*G)-D(P*TP*TP*AP*TP*GP*AP*TP*TP*C)-3')	polymer	10	3066.0	2		Homo sapiens
3	D, F (E, H)	DNA (5'-D(*GP*AP*AP*TP*CP*AP*TP*AP*AP*C)-3')	polymer	10	3037.0	2		Homo sapiens
4	G, M (A, B)	ADENOSINE MONOPHOSPHATE	non-polymer		347.2	2	Chemie (AMP) PubChem (16397049) PubChem (16760266) PubChem (224) PubChem (40467049) PubChem (40469468) PubChem (34768) PubChem (44348067) PubChem (83862) PubChem (45358029) PubChem (46874558) PubChem (40459109) PubChem (57358045) PubChem (57879893) PubChem (57879902) PubChem (46875232) PubChem (446048) PubChem (515384) PubChem (638042) PubChem (177678969) PubChem (6083) PubChem (1549371) PubChem (5316444) PubChem (92144436) PubChem (5742864) PubChem (122197642) PubChem (12358354) PubChem (12163610) PubChem (12358355) PubChem (162290139) PubChem (162946266) PubChem (171699505)
5	H, N (A, B)	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
6	I (A)	SODIUM ION	non-polymer		23.0	1	Chemie (NA) PubChem (923)
7	J, O (A, B)	BETA-MERCAPTOETHANOL	non-polymer		78.1	2	Chemie (BME)
8	K, L (A)	GLYCEROL	non-polymer		92.1	2	Chemie (GOL) PubChem (753)
9	P, Q, R, S, T... (A, B, D, E, G...)	water	water		18.0	759	Chemie (HOH)

Sequence modifications

A, B: 165 - 340 (UniProt: Q7Z2E3)

PDB	External Database	Details
Gly 161	-	expression tag
Ser 162	-	expression tag
His 163	-	expression tag
Met 164	-	expression tag
Gln 201	His 215	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	54247.1
Non-Polymers*	Number of molecules	9
	Total formula weight	1188.7
All*	Total formula weight	55435.8

*Water molecules are not included.