6CVQ
Human Aprataxin (Aptx) H201Q bound to RNA-DNA, AMP and Zn product complex
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 18 |
| Details | binding site for residue AMP A 401 |
| Chain | Residue |
| A | LEU171 |
| A | SER255 |
| A | MET256 |
| A | HIS260 |
| A | HIS262 |
| A | HOH535 |
| A | HOH603 |
| A | HOH610 |
| A | HOH613 |
| D | G1 |
| A | SER174 |
| A | ASP193 |
| A | LYS194 |
| A | TYR195 |
| A | LYS197 |
| A | GLN201 |
| A | HIS251 |
| A | PRO254 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 402 |
| Chain | Residue |
| A | CYS319 |
| A | CYS322 |
| A | HIS335 |
| A | HIS339 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue NA A 403 |
| Chain | Residue |
| A | SER255 |
| A | HOH705 |
| A | HOH815 |
| D | HOH132 |
| D | HOH139 |
| D | HOH141 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue BME A 404 |
| Chain | Residue |
| A | TYR195 |
| A | CYS272 |
| A | LYS274 |
| A | HOH507 |
| B | GLN298 |
| D | DT3 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 405 |
| Chain | Residue |
| A | ASP307 |
| A | GLY308 |
| A | PRO310 |
| A | GLU311 |
| A | HOH562 |
| B | LYS194 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 406 |
| Chain | Residue |
| A | ASP185 |
| A | GLU186 |
| A | GLN187 |
| A | HOH513 |
| A | HOH645 |
| A | HOH667 |
| site_id | AC7 |
| Number of Residues | 22 |
| Details | binding site for residue AMP B 401 |
| Chain | Residue |
| B | LEU171 |
| B | SER174 |
| B | ILE191 |
| B | LYS192 |
| B | ASP193 |
| B | LYS194 |
| B | TYR195 |
| B | LEU203 |
| B | HIS251 |
| B | SER255 |
| B | MET256 |
| B | HIS260 |
| B | HIS262 |
| B | HOH505 |
| B | HOH517 |
| B | HOH526 |
| B | HOH563 |
| B | HOH581 |
| B | HOH592 |
| B | HOH621 |
| B | HOH646 |
| G | G1 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 402 |
| Chain | Residue |
| B | CYS319 |
| B | CYS322 |
| B | HIS335 |
| B | HIS339 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | binding site for residue BME B 403 |
| Chain | Residue |
| B | TYR195 |
| B | PRO271 |
| B | CYS272 |
| B | LYS274 |
| G | DT3 |
| G | HOH105 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 210 |
| Details | Domain: {"description":"HIT","evidences":[{"source":"PROSITE-ProRule","id":"PRU00464","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 44 |
| Details | Zinc finger: {"description":"C2H2-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00042","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"17276982","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"24362567","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 10 |
| Details | Region: {"description":"Interaction with DNA substrate","evidences":[{"source":"PubMed","id":"24362567","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 8 |
| Details | Motif: {"description":"Histidine triad motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU00464","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"24362567","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Tele-AMP-histidine intermediate","evidences":[{"source":"PubMed","id":"24362567","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 8 |
| Details | Site: {"description":"Interaction with DNA substrate","evidences":[{"source":"PubMed","id":"24362567","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
