6CVF

Crystal structure of Mycobacterium tuberculosis dethiobiotin synthetase in complex with cytidine diphosphate

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	ATP-dependent dethiobiotin synthetase BioD	polymer	235	23473.9	4	UniProt (P9WPQ5) Pfam (PF13500)	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	DTB synthetase,DTBS,Dethiobiotin synthase
2	E, G, H, J (A, B, C, D)	CYTIDINE-5'-DIPHOSPHATE	non-polymer		403.2	4	Chemie (CDP)
3	F, I, K (A, C, D)	MAGNESIUM ION	non-polymer		24.3	3	Chemie (MG)
4	L, M, N, O (A, B, C, D)	water	water		18.0	1034	Chemie (HOH)

Sequence modifications

A, B, C, D: 2 - 226 (UniProt: P9WPQ5)

PDB	External Database	Details
Met -8	-	initiating methionine
Gly -7	-	expression tag
His -6	-	expression tag
His -5	-	expression tag
His -4	-	expression tag
His -3	-	expression tag
His -2	-	expression tag
His -1	-	expression tag
Gly 0	-	expression tag
Gly 1	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	93895.7
Non-Polymers*	Number of molecules	7
	Total formula weight	1685.6
All*	Total formula weight	95581.3

*Water molecules are not included.