6CTZ
Structure of the GDP and kanamycin complex of APH(2")-IIia
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Gentamicin resistance protein | polymer | 297 | 33766.2 | 1 | UniProt (P96762) Pfam (PF01636) | Enterococcus gallinarum | aminoglycoside-2"-phosphotransferase-IIIa |
| 2 | B (A) | GUANOSINE-5'-DIPHOSPHATE | non-polymer | 443.2 | 1 | Chemie (GDP) | |||
| 3 | C, D (A) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 4 | E (A) | KANAMYCIN A | non-polymer | 484.5 | 1 | Chemie (KAN) | |||
| 5 | F, G (A) | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
| 6 | H (A) | water | water | 18.0 | 369 | Chemie (HOH) |
Sequence modifications
A: 5 - 301 (UniProt: P96762)
| PDB | External Database | Details |
|---|---|---|
| Leu 108 | Phe 108 | engineered mutation |
| Leu 258 | His 258 | engineered mutation |
| Ile 290 | Leu 290 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 33766.2 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1047.2 | |
| All* | Total formula weight | 34813.4 |
