6CT9
Structure of the human cGAS-DNA complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Cyclic GMP-AMP synthase | polymer | 367 | 42875.3 | 1 | UniProt (Q8N884) Pfam (PF03281) Pfam (PF20266) | Homo sapiens (Human) | h-cGAS,2'3'-cGAMP synthase,Mab-21 domain-containing protein 1 |
| 2 | B (B) | DNA (5'-D(P*CP*GP*TP*CP*TP*TP*CP*GP*GP*CP*AP*AP*T)-3') | polymer | 17 | 5159.3 | 1 | synthetic construct | ||
| 3 | C (C) | DNA (5'-D(*AP*AP*AP*TP*TP*GP*CP*CP*GP*AP*AP*GP*AP*CP*GP*A)-3') | polymer | 17 | 5253.5 | 1 | synthetic construct | ||
| 4 | D (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 5 | E, F, G (A, B, C) | water | water | 18.0 | 103 | Chemie (HOH) |
Sequence modifications
A: 157 - 522 (UniProt: Q8N884)
| PDB | External Database | Details |
|---|---|---|
| Ser 156 | - | expression tag |
| Asn 187 | Lys 187 | engineered mutation |
| Arg 195 | Leu 195 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 53288.1 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 65.4 | |
| All* | Total formula weight | 53353.5 |
