6CQI
2.42A Crystal structure of Mycobacterium tuberculosis Topoisomerase I in complex with an oligonucleotide MTS2-11
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | DNA topoisomerase 1 | polymer | 706 | 77843.5 | 1 | UniProt (P9WG49) Pfam (PF01751) Pfam (PF01131) Pfam (PF13368) | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) | DNA topoisomerase I,Omega-protein,Relaxing enzyme,Swivelase,Untwisting enzyme |
| 2 | B (B) | DNA (5'-D(P*TP*TP*CP*CP*GP*CP*TP*TP*GP*A)-3') | polymer | 11 | 3300.2 | 1 | Mycobacterium tuberculosis | ||
| 3 | C, D (A) | FORMIC ACID | non-polymer | 46.0 | 2 | Chemie (FMT) | |||
| 4 | E (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 5 | F, G, H (A) | ACETATE ION | non-polymer | 59.0 | 3 | Chemie (ACT) | |||
| 6 | I, J (A, B) | water | water | 18.0 | 18 | Chemie (HOH) |
Sequence modifications
A: 2 - 704 (UniProt: P9WG49)
| PDB | External Database | Details |
|---|---|---|
| Ser -1 | - | expression tag |
| Asn 0 | - | expression tag |
| Ala 1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 81143.7 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 361.3 | |
| All* | Total formula weight | 81504.9 |
