6CQ1
BCL6 BTB domain in complex with 15a
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | B-cell lymphoma 6 protein | polymer | 131 | 14916.3 | 2 | UniProt (P41182) Pfam (PF00651) | Homo sapiens (Human) | BCL-6,B-cell lymphoma 5 protein,BCL-5,Protein LAZ-3,Zinc finger and BTB domain-containing protein 27,Zinc finger protein 51 |
| 2 | C, D (A, B) | 2-{6-({[2-(1H-indol-3-yl)ethyl]carbamothioyl}amino)-3-[(4-methylpiperazin-1-yl)methyl]-1H-indol-1-yl}-N-(propan-2-yl)acetamide | non-polymer | 545.7 | 2 | Chemie (F8J) | |||
| 3 | E, F (A, B) | water | water | 18.0 | 237 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 129 (UniProt: P41182)
| PDB | External Database | Details |
|---|---|---|
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
| Gln 8 | Cys 8 | engineered mutation |
| Arg 67 | Cys 67 | engineered mutation |
| Asn 84 | Cys 84 | engineered mutation |
| Val 99 | Glu 99 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 29832.6 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 1091.5 | |
| All* | Total formula weight | 30924.1 |
