6CNI

Crystal structure of H105A PGAM5 dimer

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Serine/threonine-protein phosphatase PGAM5, mitochondrial	polymer	223	25407.9	2	UniProt (Q96HS1) Pfam (PF00300)	Homo sapiens (Human)	Bcl-XL-binding protein v68,Phosphoglycerate mutase family member 5
2	C, D, E, G, H... (A, B)	SODIUM ION	non-polymer		23.0	6	Chemie (NA)
3	F, J (A, B)	PHOSPHATE ION	non-polymer		95.0	2	Chemie (PO4)
4	K, L (A, B)	water	water		18.0	308	Chemie (HOH)

Sequence modifications

A, B: 90 - 289 (UniProt: Q96HS1)

PDB	External Database	Details
Met 67	-	initiating methionine
His 68	-	expression tag
His 69	-	expression tag
His 70	-	expression tag
His 71	-	expression tag
His 72	-	expression tag
His 73	-	expression tag
Ser 74	-	expression tag
Ser 75	-	expression tag
Gly 76	-	expression tag
Val 77	-	expression tag
Asp 78	-	expression tag
Leu 79	-	expression tag
Gly 80	-	expression tag
Thr 81	-	expression tag
Glu 82	-	expression tag
Asn 83	-	expression tag
Leu 84	-	expression tag
Tyr 85	-	expression tag
Phe 86	-	expression tag
Gln 87	-	expression tag
Ser 88	-	expression tag
Met 89	-	expression tag
Ala 105	His 105	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	50815.8
Non-Polymers*	Number of molecules	8
	Total formula weight	327.9
All*	Total formula weight	51143.7

*Water molecules are not included.