6CJE
Crystal Structure of Mnk2-D228G in complex with Inhibitor
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | MAP kinase-interacting serine/threonine-protein kinase 2 | polymer | 316 | 35604.5 | 1 | UniProt (Q9HBH9) Pfam (PF00069) In PDB | Homo sapiens (Human) | MAP kinase signal-integrating kinase 2,Mnk2 |
2 | A | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
3 | A | 4-[(9H-purin-6-yl)amino]benzamide | non-polymer | 254.2 | 1 | Chemie (F4A) | |||
4 | water | water | 18.0 | 13 | Chemie (HOH) |
Sequence modifications
A: 72 - 385 (UniProt: Q9HBH9)
PDB | External Database | Details |
---|---|---|
Gly 70 | - | expression tag |
Ser 71 | - | expression tag |
Gly 228 | Asp 228 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 35604.5 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 319.7 | |
All* | Total formula weight | 35924.1 |