6CJ5
Crystal Structure of Mnk2-D228G in Complex With Inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | MAP kinase-interacting serine/threonine-protein kinase 2 | polymer | 316 | 35604.5 | 1 | UniProt (Q9HBH9) Pfam (PF00069) In PDB | Homo sapiens (Human) | MAP kinase signal-integrating kinase 2,Mnk2 |
| 2 | A | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 3 | A | 3-(pyridin-3-yl)imidazo[1,2-a]pyridine-8-carboxamide | non-polymer | 238.2 | 1 | Chemie (F4G) | |||
| 4 | water | water | 18.0 | 8 | Chemie (HOH) |
Sequence modifications
A: 72 - 385 (UniProt: Q9HBH9)
| PDB | External Database | Details |
|---|---|---|
| Gly 70 | - | expression tag |
| Ser 71 | - | expression tag |
| Gly 228 | Asp 228 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 35604.5 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 303.7 | |
| All* | Total formula weight | 35908.1 |
