6CHZ

Estrogen Receptor Alpha Y537S bound to antagonist H3B-9224.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Estrogen receptor	polymer	263	30133.2	1	UniProt (P03372) Pfam (PF00104)	Homo sapiens (Human)	ER,ER-alpha,Estradiol receptor,Nuclear receptor subfamily 3 group A member 1
2	B (A)	4-[(2-{4-[(1E)-1-(1H-indazol-5-yl)-2-phenylbut-1-en-1-yl]phenoxy}ethyl)amino]-N,N-dimethylbutanamide	non-polymer		496.6	1	Chemie (F3D)
3	C (A)	1,2-ETHANEDIOL	non-polymer		62.1	1	Chemie (EDO)
4	D (A)	water	water		18.0	111	Chemie (HOH)

Sequence modifications

A: 307 - 554 (UniProt: P03372)

PDB	External Database	Details
Met 292	-	initiating methionine
Gly 293	-	expression tag
His 294	-	expression tag
His 295	-	expression tag
His 296	-	expression tag
His 297	-	expression tag
His 298	-	expression tag
His 299	-	expression tag
Glu 300	-	expression tag
Asn 301	-	expression tag
Leu 302	-	expression tag
Tyr 303	-	expression tag
Phe 304	-	expression tag
Gln 305	-	expression tag
Leu 306	-	expression tag
Ser 381	Cys 381	engineered mutation
Ser 417	Cys 417	engineered mutation
Ser 537	Tyr 537	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	30133.2
Non-Polymers*	Number of molecules	2
	Total formula weight	558.7
All*	Total formula weight	30691.9

*Water molecules are not included.