6CHZ
Estrogen Receptor Alpha Y537S bound to antagonist H3B-9224.
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Estrogen receptor | polymer | 263 | 30133.2 | 1 | UniProt (P03372) Pfam (PF00104) In PDB | Homo sapiens (Human) | ER,ER-alpha,Estradiol receptor,Nuclear receptor subfamily 3 group A member 1 |
2 | A | 4-[(2-{4-[(1E)-1-(1H-indazol-5-yl)-2-phenylbut-1-en-1-yl]phenoxy}ethyl)amino]-N,N-dimethylbutanamide | non-polymer | 496.6 | 1 | Chemie (F3D) | |||
3 | A | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
4 | water | water | 18.0 | 111 | Chemie (HOH) |
Sequence modifications
A: 307 - 554 (UniProt: P03372)
PDB | External Database | Details |
---|---|---|
Met 292 | - | initiating methionine |
Gly 293 | - | expression tag |
His 294 | - | expression tag |
His 295 | - | expression tag |
His 296 | - | expression tag |
His 297 | - | expression tag |
His 298 | - | expression tag |
His 299 | - | expression tag |
Glu 300 | - | expression tag |
Asn 301 | - | expression tag |
Leu 302 | - | expression tag |
Tyr 303 | - | expression tag |
Phe 304 | - | expression tag |
Gln 305 | - | expression tag |
Leu 306 | - | expression tag |
Ser 381 | Cys 381 | engineered mutation |
Ser 417 | Cys 417 | engineered mutation |
Ser 537 | Tyr 537 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 30133.2 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 558.7 | |
All* | Total formula weight | 30691.9 |