6CHZ
Estrogen Receptor Alpha Y537S bound to antagonist H3B-9224.
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 9 |
| Details | binding site for residue F3D A 601 |
| Chain | Residue |
| A | LEU346 |
| A | THR347 |
| A | ALA350 |
| A | ASP351 |
| A | GLU353 |
| A | LEU387 |
| A | ARG394 |
| A | LEU428 |
| A | GLY521 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | binding site for residue EDO A 602 |
| Chain | Residue |
| A | ILE386 |
| A | LEU387 |
| A | GLY390 |
| A | PHE445 |
| A | LYS449 |
| A | HOH709 |
| A | HOH772 |
| A | HOH784 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:9338790, ECO:0000269|PubMed:9600906, ECO:0007744|PDB:1A52, ECO:0007744|PDB:1ERE |
| Chain | Residue | Details |
| A | GLU353 | |
| A | ARG394 | |
| A | HIS524 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphotyrosine; by Tyr-kinases => ECO:0000269|PubMed:7539106 |
| Chain | Residue | Details |
| A | SER537 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | LIPID: S-palmitoyl cysteine => ECO:0000250 |
| Chain | Residue | Details |
| A | CYS447 |
