6CHW
Estrogen Receptor Alpha Y537S covalently bound to antagonist H3B-5942.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Estrogen receptor | polymer | 246 | 28036.0 | 1 | UniProt (P03372) Pfam (PF00104) | Homo sapiens (Human) | ER,ER-alpha,Estradiol receptor,Nuclear receptor subfamily 3 group A member 1 |
| 2 | B (A) | 4-[(2-{4-[(1E)-1-(1H-indazol-5-yl)-2-phenylbut-1-en-1-yl]phenoxy}ethyl)amino]-N,N-dimethylbutanamide | non-polymer | 496.6 | 1 | Chemie (F3D) | |||
| 3 | C, D, E (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 3 | Chemie (EDO) | |||
| 4 | F (A) | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 1 | Chemie (DMS) | |||
| 5 | G (A) | water | water | 18.0 | 150 | Chemie (HOH) |
Sequence modifications
A: 306 - 551 (UniProt: P03372)
| PDB | External Database | Details |
|---|---|---|
| Ser 381 | Cys 381 | engineered mutation |
| Ser 417 | Cys 417 | engineered mutation |
| Ser 537 | Tyr 537 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 28036.0 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 761.0 | |
| All* | Total formula weight | 28796.9 |
