6CHW
Estrogen Receptor Alpha Y537S covalently bound to antagonist H3B-5942.
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 14 |
| Details | binding site for residue F3D A 601 |
| Chain | Residue |
| A | LEU346 |
| A | LYS529 |
| A | CYS530 |
| A | EDO603 |
| A | HOH710 |
| A | HOH748 |
| A | THR347 |
| A | ALA350 |
| A | GLU353 |
| A | LEU387 |
| A | ARG394 |
| A | GLY521 |
| A | LEU525 |
| A | MET528 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | binding site for residue EDO A 602 |
| Chain | Residue |
| A | SER381 |
| A | ALA382 |
| A | TRP383 |
| A | LEU384 |
| A | GLU385 |
| A | SER518 |
| A | MET522 |
| A | HOH751 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 603 |
| Chain | Residue |
| A | ALA350 |
| A | ASP351 |
| A | TRP383 |
| A | F3D601 |
| A | HOH758 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | binding site for residue EDO A 604 |
| Chain | Residue |
| A | GLU323 |
| A | TRP393 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue DMS A 605 |
| Chain | Residue |
| A | HIS476 |
| A | LEU479 |
| A | ASP480 |
| A | GLN506 |
| A | LEU509 |
| A | HOH717 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 236 |
| Details | Domain: {"description":"NR LBD","evidences":[{"source":"PROSITE-ProRule","id":"PRU01189","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"9338790","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9600906","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1A52","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1ERE","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphotyrosine; by Tyr-kinases","evidences":[{"source":"PubMed","id":"7539106","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Lipidation: {"description":"S-palmitoyl cysteine","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
